Acute Exposure to a Precursor of Advanced Glycation End Products Induces a Dual Effect on the Rat Pancreatic Islet Function

Figure 2

Effect of acetylcholine or epinephrine on GSIS. Insulin secretion was stimulated or inhibited by acetylcholine or epinephrine, as indicated below the -axis, in absence or presence of methylglyoxal. Bars represent the mean ± S.E.M. of the percentage of insulin release compared with their respective glucose concentrations, which are represented by the line from 0. Ach, 10 μM of acetylcholine in presence of 10 μM of neostigmine + 8.3 mM of glucose; Epi, 1 μM epinephrine + 16.7 mM of glucose. compared with 8.3 mM of glucose; ^# compared with 16.7 mM of glucose; ^∗ and ^∗∗ compared with the respective control group.