Acute Exposure to a Precursor of Advanced Glycation End Products Induces a Dual Effect on the Rat Pancreatic Islet Function

Figure 3

Effect of K⁺, forskolin, or leucine on GSIS. Insulin secretion was stimulated or inhibited by K⁺, forskolin, or leucine, as indicated below the -axis, in absence or presence of methylglyoxal. Bars represent the mean ± S.E.M. of the percentage of insulin release compared with their respective glucose concentrations, which are represented by the line from 0. K⁺, 40 mM of potassium + 5.6 mM of glucose; forskolin, 10 μM of forskolin + 8.3 mM of glucose; leucine, 10 mM of leucine + 5.6 mM of glucose. compared with 5.6 mM of glucose; compared with 8.3 mM of glucose; ^# compared with 16.7 mM of glucose; ^∗ and ^∗∗ compared with the respective control group.