|
| Gene symbol | Fold
change | Gene
ID | Description |
|
| Upregulated genes: 40 transcripts |
Cytokines/membrane
proteins/immunological factors | | | |
| NLRC5 | 14.1 | 84166 | NLR family, CARD domain containing 5 |
| IL15 | 5.8 | 3600 | Interleukin-15 |
| IFIT3 | 5.8 | 3437 | Interferon-induced protein with tetratricopeptide repeats 3 |
| CXCL10 | 3.1 | 3627 | Chemokine (C-X-C motif) ligand 10 |
| IFIH1 | 2.9 | 64135 | Interferon induced with helicase C domain 1 |
| IFIT5 | 2.8 | 24138 | Interferon-induced protein with tetratricopeptide repeats 5 |
| IL-15RA | 2.7 | 3601 | Interleukin-15 receptor, alpha |
| VEGFC | 2.5 | 7424 | Vascular endothelial growth factor C |
| PDCD1LG2 | 2.5 | 80380 | Programmed cell death 1 ligand 2 |
| Transporters | | | |
| TAP1 | 3.4 | 6890 | Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| TAP2 | 2.6 | 6891 | Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| APOL3 | 2.1 | 80833 | Apolipoprotein L, 3 |
| VLDLR | 2.1 | 7436 | Very low density lipoprotein receptor |
| APOL2 | 2.1 | 23780 | Apolipoprotein L, 2 |
| Structural factors | | | |
| LMNB1 | 4.3 | 4001 | Lamin B1 |
| Transcription | | | |
| IRF1 | 11 | 3659 | Interferon regulatory factor 1 |
| IRF9 | 4.9 | 10379 | Interferon regulatory factor 9 |
| STAT1 | 4.5 | 6772 | Signal transducer and activator of transcription 1, 91 kda |
| TAF15 | 2.1 | 8148 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kda |
| Cell-cell adhesion | | | |
| ICAM1 | 5.1 | 3383 | Intercellular adhesion molecule 1 |
| Ion binding | | | |
| C1S | 3.2 | 716 | Complement component 1, s subcomponent |
| SP110 | 2.9 | 3431 | SP110 nuclear body protein |
| PARP12 | 2.3 | 64761 | Poly (ADP-ribose) polymerase family, member 12 |
| ZC3HAV1 | 2.3 | 56829 | Zinc finger CCCH-type, antiviral 1 |
| Tryptophan metabolism | | | |
| IDO1 | 6.2 | 3620 | Indoleamine 2,3-dioxygenase 1 |
| WARS | 4.2 | 7453 | Tryptophanyl-trna synthetase |
| Enzyme activity | | | |
| DTX3L | 4.6 | 151636 | Deltex 3-like (Drosophila) |
| PSMB9 | 3.3 | 5698 | Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) |
| MSRB1 | 2.5 | 51734 | Methionine sulfoxide reductase B1 |
| CTSZ | 2.2 | 1522 | Cathepsin Z |
| Nucleotide metabolism | | | |
| GBP5 | 10.5 | 115362 | Guanylate binding protein 5 |
| GBP1 | 5.8 | 2633 | Guanylate binding protein 1, interferon-inducible |
| PARP14 | 5.2 | 54625 | Poly (ADP-ribose) polymerase family, member 14 |
| GBP2 | 3.2 | 2634 | Guanylate binding protein 2, interferon-inducible |
| MX1 | 2.5 | 4599 | Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
| RAD23B | 2.3 | 5887 | RAD23 homolog B (S. Cerevisiae) |
| GBP7 | 2 | 388646 | Guanylate binding protein 7 |
| Others | | | |
| FAM117B | 3.6 | 150864 | Family with sequence similarity 117, member B |
| C19orf66 | 2.6 | 55337 | Chromosome 19 open reading frame 66 |
| NUB1 | 2.5 | 51667 | Negative regulator of ubiquitin-like proteins 1 |
|
| Downregulated genes: 129 transcripts |
| Cytokines/membrane proteins/immunological factors | | | |
| IL36G | −3.4 | 56300 | Interleukin-36, gamma |
| IL33 | −3.0 | 90865 | Interleukin-33 |
| IL1RN | −2.5 | 3557 | Interleukin-1 receptor antagonist |
| DNAJB14 | −2.5 | 79982 | Dnaj (Hsp40) homolog, subfamily B, member 14 |
| KITLG | −2.3 | 4254 | KIT ligand |
| LARP4 | −2.3 | 113251 | La ribonucleoprotein domain family, member 4 |
| CLDN4 | −2.2 | 1364 | Claudin 4 |
| CUL5 | −2.2 | 8065 | Cullin 5 |
| Intracellular/signalling factors | | | |
| ITGB8 | −3.5 | 3696 | Integrin, beta 8 |
| RICTOR | −2.8 | 253260 | RPTOR independent companion of MTOR, complex 2 |
| IL6ST | −2.6 | 3572 | Interleukin-6 signal transducer (gp130, oncostatin M receptor) |
| SOCS4 | −2.5 | 122809 | Suppressor of cytokine signaling 4 |
| NRIP1 | −2.5 | 8204 | Nuclear receptor interacting protein 1 |
| SEMA3A | −2.5 | 10371 | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
| PLCB4 | −2.2 | 5332 | Phospholipase C, beta 4 |
| COPS2 | −2.2 | 9318 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) |
| BMPR2 | −2 | 659 | Bone morphogenetic protein receptor, type II (serine/threonine kinase) |
| Transporters | | | |
| TPR | −3.4 | 7175 | Translocated promoter region, nuclear basket protein |
| KIAA1033 | −2.5 | 23325 | Kiaa1033 |
| BAZ2B | −2.5 | 29994 | Bromodomain adjacent to zinc finger domain, 2B |
| TMED5 | −2.2 | 50999 | Transmembrane emp24 protein transport domain containing 5 |
| SLC4A7 | −2 | 9497 | Solute carrier family 4, sodium bicarbonate cotransporter, member 7 |
| Structural factors | | | |
| ROCK2 | −2.9 | 9475 | Rho-associated, coiled-coil containing protein kinase 2 |
| Transcription | | | |
| BDP1 | −3.6 | 55814 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB |
| TRIP11 | −3.4 | 9321 | Thyroid hormone receptor interactor 11 |
| ZNF644 | −3.3 | 84146 | Zinc finger protein 644 |
| CHD9 | −3.2 | 80205 | Chromodomain helicase DNA binding protein 9 |
| ZNF480 | −3.1 | 147657 | Zinc finger protein 480 |
| ZNF292 | −3 | 23036 | Zinc finger protein 292 |
| ZNF148 | −2.8 | 7707 | Zinc finger protein 148 |
| ZNF267 | −2.8 | 10308 | Zinc finger protein 267 |
| ZBTB20 | −2.7 | 26137 | Zinc finger and BTB domain containing 20 |
| CREB1 | −2.7 | 1385 | Camp responsive element binding protein 1 |
| ZNF638 | −2.6 | 27332 | Zinc finger protein 638 |
| ZNF518A | −2.6 | 9849 | Zinc finger protein 518A |
| ESF1 | −2.6 | 51575 | ESF1, nucleolar pre-rrna processing protein, homolog (S. Cerevisiae) |
| FAR1 | −2.6 | 84188 | Fatty acyl coa reductase 1 |
| ZNF91 | −2.5 | 7644 | Zinc finger protein 91 |
| CENPF | −2.5 | 1063 | Centromere protein F, 350/400 kda (mitosin) |
| FOXN2 | −2.4 | 3344 | Forkhead box N2 |
| DNTTIP2 | −2.2 | 30836 | Deoxynucleotidyl transferase, terminal, interacting protein 2 |
| TMF1 | −2.2 | 7110 | TATA element modulatory factor 1 |
| BCLAF1 | −2.2 | 9774 | BCL2-associated transcription factor 1 |
| CEBPZ | −2.2 | 10153 | CCAAT/enhancer binding protein (C/EBP), zeta |
| ZNF146 | −2.1 | 7705 | Zinc finger protein 146 |
| HIF1A | −2 | 3091 | Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
| Cell-cell adhesion | | | |
| DST | −2.9 | 667 | Dystonin |
| Ion binding | | | |
| ATRX | −4.6 | 546 | Alpha thalassemia/mental retardation syndrome X-linked |
| EEA1 | −3.4 | 8411 | Early endosome antigen 1 |
| RSF1 | −2.6 | 51773 | Remodeling and spacing factor 1 |
| NIN | −2.6 | 51199 | Ninein (GSK3B interacting protein) |
| SCAF11 | −2.5 | 9169 | SR-related CTD-associated factor 11 |
| MIB1 | −2 | 57534 | Mind bomb E3 ubiquitin protein ligase 1 |
| TRMT13 | −2 | 54482 | Trna methyltransferase 13 homolog (S. Cerevisiae) |
| Kinase | | | |
| CCDC88A | −3.1 | 55704 | Coiled-coil domain containing 88A |
| FER | −3.1 | 2241 | Fer (fps/fes related) tyrosine kinase |
| KTN1 | −3 | 3895 | Kinectin 1 (kinesin receptor) |
| SCYL2 | −2.6 | 55681 | SCY1-like 2 (S. Cerevisiae) |
| AKAP11 | −2.5 | 11215 | A kinase (PRKA) anchor protein 11 |
| PIK3C2A | −2.5 | 5286 | Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
| CDK6 | −2.3 | 1021 | Cyclin-dependent kinase 6 |
| NEK1 | −2.3 | 4750 | NIMA (never in mitosis gene a)-related kinase 1 |
| SLK | −2.2 | 9748 | STE20-like kinase |
| UTRN | −2.2 | 7402 | Utrophin |
| RB1CC1 | −2 | 9821 | RB1-inducible coiled-coil 1 |
| YES1 | −2 | 7525 | V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
| Enzyme activity | | | |
| RANBP2 | −2.9 | 5903 | RAN binding protein 2 |
| JMJD1C | −2.7 | 221037 | Jumonji domain containing 1C |
| RNF6 | −2.7 | 6049 | Ring finger protein (C3H2C3 type) 6 |
| LTN1 | −2.6 | 26046 | Listerin E3 ubiquitin protein ligase 1 |
| RBBP6 | −2.5 | 5930 | Retinoblastoma binding protein 6 |
| PPIG | −2.5 | 9360 | Peptidylprolyl isomerase G (cyclophilin G) |
| PTAR1 | −2.4 | 375743 | Protein prenyltransferase alpha subunit repeat containing 1 |
| PYROXD1 | −2.3 | 79912 | Pyridine nucleotide-disulphide oxidoreductase domain 1 |
| LIG4 | −2.3 | 3981 | Ligase IV, DNA, ATP-dependent |
| RAD50 | −2.1 | 10111 | RAD50 homolog (S. Cerevisiae) |
| DBF4 | −2 | 10926 | DBF4 homolog (S. Cerevisiae) |
| Nucleotide metabolism | | | |
| CHD1 | −2.6 | 1105 | Chromodomain helicase DNA binding protein 1 |
| CHML | −2.5 | 1122 | Choroideremia-like (Rab escort protein 2) |
| ELMOD2 | −2.1 | 255520 | ELMO/CED-12 domain containing 2 |
| NAA15 | −2 | 80155 | N(alpha)-acetyltransferase 15, nata auxiliary subunit |
| KIF20B | −2 | 9585 | Kinesin family member 20B |
| Others | | | |
| GOLGA4 | −3.9 | 2803 | Golgin A4 |
| ASPM | −3.4 | 259266 | Asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| CEP350 | −3.3 | 9857 | Centrosomal protein 350 kda |
| C10orf118 | −3.2 | 55088 | Chromosome 10 open reading frame 118 |
| GALNT5 | −3.2 | 11227 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (galnac-T5) |
| BOD1L1 | −3.1 | 259282 | Biorientation of chromosomes in cell division 1-like 1 |
| ANKRD12 | −3.1 | 23253 | Ankyrin repeat domain 12 |
| RIF1 | −3 | 55183 | RAP1 interacting factor homolog (yeast) |
| KIAA2026 | −3 | 158358 | Kiaa2026 |
| FAM111B | −2.9 | 374393 | Family with sequence similarity 111, member B |
| EIF5B | −2.8 | 9669 | Eukaryotic translation initiation factor 5B |
| OSBPL8 | −2.8 | 114882 | Oxysterol binding protein-like 8 |
| GOLGB1 | −2.8 | 2804 | Golgin B1 |
| MALAT1 | −2.7 | 378938 | Metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) |
| PRPF40A | −2.7 | 55660 | PRP40 pre-mrna processing factor 40 homolog A (S. Cerevisiae) |
| QSER1 | −2.6 | 79832 | Glutamine and serine rich 1 |
| THOC2 | −2.6 | 57187 | THO complex 2 |
| RASSF6 | −2.6 | 166824 | Ras association (ralgds/AF-6) domain family member 6 |
| STAG2 | −2.6 | 10735 | Stromal antigen 2 |
| NUFIP2 | −2.5 | 57532 | Nuclear fragile X mental retardation protein interacting protein 2 |
| SMC2 | −2.5 | 10592 | Structural maintenance of chromosomes 2 |
| SLC30A1 | −2.5 | 7779 | Solute carrier family 30 (zinc transporter), member 1 |
| ZNF268 | −2.4 | 10795 | Zinc finger protein 268 |
| KIAA1109 | −2.4 | 84162 | Kiaa1109 |
| NIPBL | −2.4 | 25836 | Nipped-B homolog (Drosophila) |
| ANKRD30BP2 | −2.4 | 149992 | Ankyrin repeat domain 30B pseudogene 2 |
| KIF5B | −2.4 | 3799 | Kinesin family member 5B |
| SMC4 | −2.3 | 10051 | Structural maintenance of chromosomes 4 |
| SMC5 | −2.3 | 23137 | Structural maintenance of chromosomes 5 |
| NEMF | −2.3 | 9147 | Nuclear export mediator factor |
| GCC2 | −2.3 | 9648 | GRIP and coiled-coil domain containing 2 |
| EXOC5 | −2.3 | 10640 | Exocyst complex component 5 |
| FCHO2 | −2.3 | 115548 | FCH domain only 2 |
| SMC6 | −2.3 | 79677 | Structural maintenance of chromosomes 6 |
| HOOK3 | −2.2 | 84376 | Hook homolog 3 (Drosophila) |
| LGALSL | −2.1 | 29094 | Lectin, galactoside-binding-like |
| SEMA3C | −2.1 | 10512 | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| TMEM106B | −2.1 | 54664 | Transmembrane protein 106B |
| PCM1 | −2.1 | 5108 | Pericentriolar material 1 |
| KRTAP2-3 | −2.1 | 730755 | Keratin associated protein 2-3 |
| MACC1 | −2.1 | 346389 | Metastasis associated in colon cancer 1 |
| CCDC82 | −2.1 | 79780 | Coiled-coil domain containing 82 |
| TTC37 | −2.1 | 9652 | Tetratricopeptide repeat domain 37 |
| UACA | −2.1 | 55075 | Uveal autoantigen with coiled-coil domains and ankyrin repeats |
| CEP290 | −2 | 80184 | Centrosomal protein 290 kda |
| USP53 | −2 | 54532 | Ubiquitin specific peptidase 53 |
| METRNL | −2 | 284207 | Meteorin, glial cell differentiation regulator-like |
|
