Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway

Figure 1

LA dose-dependently regulated high glucose-induced proliferation of rat mesangial cells. Proliferation of mesangial cells was determined by MTT assay. LA accelerated mesangial cell proliferation induced by high glucose for 12, 24, or 48 h, at final concentrations of 0.1, 0.25 mmol/L, respectively, while cell proliferation caused by high glucose was inhibited as the dose of LA increased to >0.5 mmol/L. Values are given as mean ± SD () and was considered statistically significant. Note: ^* versus NG; ^# versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 2 5 mM mannitol); HG, high glucose (30 mM).