Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway

Figure 6

MTT assay for cell proliferation analysis. LY294002 dose-dependently inhibited mesangial cell proliferation induced by 0.25 mM LA. 10 μg/mL STO-609 completely abolished the inhibition of mesangial cell proliferation, which was caused by 1.0 mM LA. Data in the bar graphs represent the mean ± SD (). was considered statistically significant. Note: ^* versus NG; ^# versus HG. Abbreviations: NG, normal glucose (5 mM); Man (5 mM glucose + 25 mM mannitol); HG, high glucose (30 mM).

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