Profiling of Somatic Mutations in Phaeochromocytoma and Paraganglioma by Targeted Next Generation Sequencing Analysis

Table 2

Oncogene mutations identified in next generation sequencing analysis of 85 PCC/PGL/HNPGL.

Tumour ID	Clinical diagnosis	Type of tumour	Gene	Codon change	Aminoacid change	Allele frequency
P19	Phaeochromocytoma	PCC	HRAS	c.37G>C	G13R	72%
P20	Phaeochromocytoma	PCC	HRAS	c.182A>G	Q61R	36%
P21	Phaeochromocytoma	PCC	HRAS	c.182A>G	Q61R	27%
P22	Phaeochromocytoma	PCC	HRAS	c.182A>G	Q61R	40%
P23	Phaeochromocytoma	PCC	HRAS	c.182A>G	Q61R	50%
P24	Phaeochromocytoma	PCC	HRAS	c.182A>G	Q61R	26%
P25	Phaeochromocytoma	PCC	BRAF	c.1799T>A	V600E	10%
P26	Phaeochromocytoma	PCC	TP53	c.1010G>A	R337H	4%
P27	Phaeochromocytoma	PCC	TP53	c.1010G>A	R337H	21%