Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

Figure 4

Effects on plasma levels of glucose, insulin, and leptin and evaluation of insulin resistance after treatment with Ole and Ac-Ole. Blood samples were collected as indicated in Methods. Glucose and hormones levels were significantly lower after treatment with Ole and Ac-Ole in animals fed with caf diet. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as indicated in Methods. Values are mean ± SD. , , and compared to STD; and compared to CAF.