Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet

Table 4

Effects of Ole and Ac-Ole on serum parameters.

Parameter	Units	STD	CAF	OLE	Ac-OLE	Range
Cholesterol	mg/dL	108.7 ± 6.2	183.0 ± 13.4	158.2 ± 23.4	158.5 ± 18.5	43.7–126.2
HDL	mg/dL	94.7 ± 3.8	136.0 ± 7.5	121.0 ± 12.3	123.2 ± 19.5	51.1–102.5
LDL	mg/dL	14.0 ± 2.7	47.0 ± 7	29.3 ± 4.7	30.7 ± 3.4	13.8–31.0
Triglycerides	mg/dL	47.0 ± 8.9	52.6 ± 3.5	39.0 ± 6.5	57.5 ± 6.5	47.1–254.9
ALT	U/L	36.5 ± 1.9	41.7 ± 2.2	28.7 ± 0.9	31.0 ± 7.8	13.3–80.2
AST	U/L	97.7 ± 11.1	169.3 ± 10.7	128.8 ± 7.4	90.0 ± 8.5	40.8–510.6

STD: mice fed with STD diet; CAF: mice fed with CAF diet; OLE: mice fed with CAF diet plus Ole at 0.037 mmol/kg/day; Ac-OLE: mice fed with CAF diet plus Ac-Ole at 0.025 mmol/kg/day; ALT: alanine aminotransferase; AST: aspartate aminotransferase; HDL: high density lipoproteins; LDL: low density lipoproteins. Reference range calculated on the data published in Mouse Database Phenomena (Jackson Laboratory) (http://phenome.jax.org). Values are mean ± SD. , , and compared to STD; , , and compared to CAF.