Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease

Table 3

Side effects (out of 242 infusions).

Side effects		%
Bradycardia 50 bpm	6	2.5
Hypertension SBP 160 mmHg and/or DBP 100 mmHg	12	5
Urticarial Rash-IVMP stopped	1	0.4
Nonspecific rashes or flushing	5	2.1
Palpitations	2	0.8
Shortness of breath	2	0.8
Chest tightness	1	0.4
Headache	6	2.5
Insomnia	2	0.8
Fever	1	0.4
Gastritis	1	0.4
Changes in LFT	0	0
Changes in ECG	0	0

SBP: systolic blood pressure, DBP: diastolic blood pressure, IVMP: intravenous methylprednisolone, LFT: liver function test, and ECG: electrocardiogram.
Documented from questionnaire after end of each infusion at 90 min.
Defined as above, 3 times of upper limit of normal.