Methylation of Promoter Regions of Genes of the Human Intrauterine Renin Angiotensin System and Their Expression

Figure 4

The proportions of hypermethylation in alleles of ACE, AGTR1, ATP6AP2, CTSD, and KLK1 and the mRNA abundance of these genes within amnion, decidua, and placenta collected from term pregnancies before the onset of labour. Significant differences were determined with Kruskal-Wallis tests using Dunn’s multiple comparison test, with significant differences to amnion denoted by * () and *** (). Data are presented as Tukey box plots with outliers displayed as filled circles.