Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines
Table 1
Change in clinical and metabolic characteristics 4 months after weight loss ( = 49).
Variable
Baseline
4 months
Age
32.29 ± 8.68
BMI (kg/m2)
39.72 ± 7.58
37.83 ± 7.61
<0.001
WC (cm)
119.01 ± 13.76
112.6 ± 14.2
<0.001
FBG (mmol/L)
5.38 ± 0.71
5.03 ± 0.69
<0.001
HOMA-IR
5.44 ± 3.9
4.47 ± 2.76
0.02
Total cholesterol (mmol/L)
4.86 ± 0.88
4.44 ± 0.84
<0.001
LDL-cholesterol (mmol/L)
3.27 ± 0.78
2.9 ± 0.71
<0.001
HDL-cholesterol (mmol/L)
1.01 ± 0.23
1 ± 0.2
0.21
Triglycerides (mmol/L)
1.26 ± 0.65
1.2 ± 0.6
0.21
hsCRP (mg/L)
9.55 ± 7.81
9.33 ± 8.26
0.23
BAP (g/L)
44.3 ± 16
35 ± 14.31
<0.001
Vitamin D (nmol/L)
34.24 ± 25.32
38.76 ± 23.95
0.06
Adiponectin (g/mL)
25.25 ± 10.61
36.3 ± 18.07
<0.001
Chemerin (ng/mL)
113.76 ± 33.41
107.6 ± 54.27
0.29
Resistin (g/mL)
28.34 ± 7.29
8.02 ± 3.38
<0.001
Total OC (ng/mL)
19.36 ± 6.6
19.59 ± 5.7
0.18
Carboxylated OC (ng/mL)
10.64 ± 5.16
11.22 ± 5.31
0.41
Undercarboxylated OC (ng/mL)
6.44 ± 5.3
10.21 ± 7.22
<0.001
Undercarboxylated/total OC
0.34 ± 0.26
0.51 ± 0.29
<0.001
Data are presented as the mean ± standard deviation. BMI: body mass index; WC: waist circumference; FBG: fasting blood glucose; HOMA-IR: homeostasis model assessment of insulin resistance; LDL: low-density lipoprotein; HDL: high-density lipoprotein; hsCRP: high-sensitivity C-reactive protein; BAP: bone-specific alkaline phosphatase; and OC: osteocalcin. The values were yielded from the baseline-versus-4-month comparison of the values for each of the measured parameters. values < 0.05 (bolded) were considered statistically significant.
