Synergy between HDAC and PARP Inhibitors on Proliferation of a Human Anaplastic Thyroid Cancer-Derived Cell Line

Table 1

Combination index data for SAHA and PJ34 combination.

Dose SAHA (M)	Dose PJ34; (M)	Combination effect; (% cell viability)^*	CI value
1.0	5.0	26	0.26979
1.0	10.0	37	0.60235
1.0	15.0	12	0.13878
1.0	30.0	13	0.18473
2.0	5.0	18	0.33123
2.0	10.0	17	0.33414
2.0	15.0	19	0.40111
2.0	30.0	11	0.25341
3.0	5.0	13	0.36504
3.0	10.0	26	0.75320
3.0	15.0	16	0.47175
3.0	30.0	14	0.45413
4.0	5.0	17	0.60763
4.0	10.0	17	0.62785
4.0	15.0	10	0.40318
4.0	30.0	13	0.53865

Mean value of four replicates. In each condition standard deviation is less than 10%.