The Impacts of SLC22A1 rs594709 and SLC47A1 rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients

Table 3

Comparisons of differential values (post-administration minus pre-administration) in T2DM patients with different SLC22A1 rs594709 and SLC47A1 rs2289669 genotypes before and after metformin treatment.

Parameter	SLC22A1 rs594709		value	SLC47A1 rs2289669		value
	AA/GA ()	GG ()		AA/GA ()	GG ()
FBG (mmol/L)						0.668
PBG (mmol/L)						0.692
FINS (mU/L)						0.501
PINS (mU/L)						0.457
HbA1c (%)						1.000
TG (mmol/L)						0.163
TChol (mmol/L)						0.030
LDL-C (mmol/L)						0.049
HDL-C (mmol/L)						0.254
HOMA-IR						0.357
HOMA-IS						0.382
HOMA-B						0.295
QUICKI						0.446

BMI: body mass index; FBG: fasting blood glucose; PBG: postprandial blood glucose; FINS: fasting insulin; PINS: postprandial insulin; HbA1c: glycosylated haemoglobin; TG: triglycerides; TChol: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-IS: homeostasis model assessment of insulin sensitivity; HOMA-B: homeostasis model assessment of β-cell function; QUICKI: quantitative insulin sensitivity check index.
for comparison of GG genotype with GA/AA genotype of SLC22A1 rs594709 polymorphism, adjusted for age, sex, and BMI, in recessive model.
for comparison of GG genotype with GA/AA genotype of SLC47A1 rs2289669 polymorphism, adjusted for age, sex, and BMI, in recessive model.