Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus

Table 5

Salivary BPIFA1 (μg/mL, median (IQR)), TNF-α, and IL-6 (pg/mL, median (IQR)) concentrations according to severity of periodontitis with or without T2DM.

	NDM				T2DM				value
	No periodontitis (G1)	Mild periodontitis (G2)	Moderate periodontitis (G3)	Severe periodontitis (G4)	No periodontitis (G5)	Mild periodontitis (G6)	Moderate periodontitis (G7)	Severe periodontitis (G8)
BPIFA1 (pg/mL) (median (IQR))	879.89 (1592.79–550.00)	626.02 (713.92–387.36)	195.08 (877.94–74.76)	1441.96 (2342.94–375.59)	110.00 (285.94–82.00)	811.28 (1316.11–115.28)	573.87 (1963.67–236.28)	188.05 (340.13–55.81)	^a; ^a
									^a; ^a
									^a; ^a
									^a; ^a
TNF-α (pg/mL) (median (IQR))	360.42 (715.93–213.74)	96.16 (270.72–10.42)	58.25 (188.67–10.38)	253.79 (364.73–38.68)	118.63 (637.59–46.44)	116.44 (425.19–50.36)	201.20 (580.28–110.35)	84.07 (228.44–19.62)	^a; ^a
									^a; ^a
									^a
IL-6 (pg/mL) (median (IQR))	3.74 (15.43–1.37)	6.33 (9.61–4.98)	9.45 (13.48–7.01)	8.66 (44.56–5.47)	10.00 (36.73–6.31)	18.15 (38.15–2.61)	15.89 (42.80–11.40)	3.89 (5.31–2.21)	^a

T2DM: type 2 diabetes mellitus; NDM: nondiabetes mellitus; BPIFA1: BPI fold containing family A, member 1; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6; BMI: body mass index. P_1,2: G1 versus G2; P_1,3: G1 versus G3; P_1,5: G1 versus G5; P_3,4: G3 versus G4; P_5,6: G5 versus G6; P_5,7: G5 versus G7; P_6,8: G6 versus G8; P_7,8: G7 versus G8; P_4,8: G4 versus G8; P_3,7: G3 versus G7. ^aAnalysis of variance (ANOVA).