A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder

Figure 4

Bone histomorphometry and histology of CKD mice. Mice were either fed with HPD for 4 (HPD4, ) or 7 days (HPD7, ) and then followed on SCD until day 84. They were compared with mice on SCD for the complete study period (SCD, ). On day 84, (a) serum Pth levels and (b) FGF23 levels were evaluated. Furthermore, mice were calcein-labelled and the tibia was analysed by using bone histomorphometry. (c) Bone volume/tissue volume (BV/TV), (d) mineral apposition rate (MAR), (e) bone formation rate (BFR), (f) eroded surface/bone surface (ES/BS), (g) osteoid surface/bone surface (OS/BS), (h) trabecular thickness (Tb.Th), (i) trabecular separation (Tb. Sp.), and (j) trabecular number (Tb.N) are provided. and .

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