Research Article
Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients
Table 2
Primer sequences for each single-nucleotide polymorphism.
| | Gene | SNP | Direction | Primer sequence (5 → 3) |
| | TLR1 | rs4833095 | F | GCCAAACCAGCTGGAGGATCC | | (+742) | R | TGGGGAACACAATGTGCAGACTC |
| | TLR2 | rs4696480 | F | CAAGATTGAAGGGCTGCATCTGG | | (−16934) | R | CCACCTCTCAGCTCGCAGTGAG | | rs1898830 | F | GAAGAGTGACGAAAAATGAATGAGCA | | (intron1) | R | GATGAACCTCTGGCAAGACAATAAAAG | | rs7656411 | F | GCCTGCCCTTTTTCCCCTTC | | (3UTR) | R | TTAAGCTGGGAACCATGTGAAAGG |
| | TLR3 | rs3775291 | F | TGGCCCAACCAAGAGAAAGCA | | (c.1243) | R | TGGGGAGTGAGGCAAGGGAA | | rs3775296 | F | CCAATGCATTTGAAAGCCATCTG | | (−7) | R | CCTTTTGCCCTTTGGGATGC |
| | TLR4 | rs11536889 | F | TGGGCAATGCTCCTTGACCAC | | (3UTR) | R | GGACAATCAGGATGTCATCAGGGA | | rs10759932 | F | CACTTGCTACTTTCCAGACACTGTCCT | | (−1607) | R | TGAGAACTCCTGTACACCATTTGTGG | | rs1927911 | F | TGGCCCAGATTTTGACAACTGC | | (intron1) | R | CATGGATTCCCATGGTGGAACC |
| | TLR5 | rs5744168 | F | TCTGGGGGAACTTTACAGTTCGAA | | | (+1174) | R | TGCCAAAGATCAACCTTACAGCG |
| | TLR6 | rs5743810 | F | CCCTTCACCTTGTTTTTCACCCA | | (+745) | R | CTTGGAAATGCCTGGTCAGAGTCT | | rs2381289 | F | CTGCAAGGAAGGCCAAGCAGA | | (3UTR) | R | TGAAGCCCTCGCTTTCTGGACT |
| | TLR9 | rs352140 | F | CGCTGACCGGTCTGCAGGT | | (+2848) | R | ACTGGAGGCCCTGGACCTCA | | rs187084 | F | ACTGGATCCTGGGGATGCAGA | | (−1486) | R | AGCTGACATTCCAGCAGGGGA | | rs352162 | F | TCTCCTGAATCTCCAGCCCCA | | (3UTR) | R | TGGCAATCCCAAGACAGGCA |
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SNP: single-nucleotide polymorphism; TLR: Toll-like receptor.
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