Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance
Table 1
The selected functional SNPs of UCP2 and PPARγ.
Gene name
SNP number
Function
Minor allele frequency
Data sources
Relevant documents
Function forecast
UCP2
rs660339
Missense
0.422
HapMap
Investigation of variants in UCP2 in Chinese type 2 diabetes and diabetic retinopathy
Splicing (ESE or ESS)/nsSNP
rs659366
Promoter
0.442
HapMap
The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy
TFBS
rs649446
Promoter
0.35
HapMap
No report
TFBS
rs586773
5 near
0.476
1000 Genomes
No report
TFBS
rs34408426
5 near
0.476
1000 Genomes
No report
TFBS
rs7109266
5 near
0.349
HapMap
No report
TFBS
rs3019463
5 near
0.476
1000 Genomes
No report
TFBS
rs591758
5 near
0.422
HapMap
Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women’s Health Initiative Observational Study
TFBS
PPARγ
rs3856806
Cds-synon
0.233
HapMap
Gene-gene interactions among PPARα/δ/γ polymorphisms for hypertriglyceridemia in Chinese Han population
—
rs2920502
Promoter
0.244
HapMap
Genetic variants in peroxisome proliferator-activated receptor-γ and retinoid X receptor-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population
