Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance
Table 8
Association of genotype with insulin secretion function and blood glucose in UCP2.
Genotype
HbA1c%
FPG (mmol/l)
Glu30 (mmol/l)
Glu60 (mmol/l)
Glu120 (mmol/l)
Ins0 (μIU/ml)
Ins30 (μIU/ml)
Ins60 (μIU/ml)
Ins120 (μIU/ml)
HOMA-IR
HOMA-β
DI30
DI120
rs660339
GG
6.06 ± 0.11
6.89 ± 0.21
11.37 ± 0.31
11.26 ± 0.42
9.66 ± 0.46
11.79 ± 0.77
78.32 ± 5.24
78.70 ± 4.76
51.97 ± 3.60
3.43 ± 0.23
88.43 ± 5.73
414.74 ± 23.47
536.01 ± 24.80
AA
5.99 ± 0.11
6.80 ± 0.23
11.23 ± 0.32
11.38 ± 0.44
9.55 ± 0.48
12.48 ± 1.16
69.12 ± 4.91
74.85 ± 4.53
57.01 ± 3.97
3.92 ± 0.43
90.93 ± 6.62
383.99 ± 27.42
514.93 ± 28.03
GA
6.01 ± 0.07
6.68 ± 0.13
11.01 ± 0.21
10.92 ± 0.29
8.83 ± 0.28
12.29 ± 0.61
71.72 ± 3.28
78.81 ± 3.47
58.45 ± 3.07
3.97 ± 0.33
89.23 ± 3.38
420.51 ± 17.56
587.96 ± 34.53
value
0.894
0.677
0.592
0.633
0.187
0.849
0.379
0.803
0.412
0.524
0.95
0.518
0.294
rs659366
CC
6.05 ± 0.11
6.88 ± 0.22
11.37 ± 0.32
11.28 ± 0.43
9.68 ± 0.47
11.80 ± 0.79
77.38 ± 5.27
78.68 ± 4.82
52.52 ± 3.68
3.43 ± 0.24
88.80 ± 5.86
410.35 ± 23.43
535.63 ± 25.18
TT
5.93 ± 0.11
6.74 ± 0.22
11.09 ± 0.31
11.07 ± 0.43
9.31 ± 0.46
12.56 ± 1.12
71.34 ± 5.05
75.55 ± 4.77
58.35 ± 4.31
3.88 ± 0.42
92.55 ± 6.54
395.63 ± 27.34
526.68 ± 27.42
TC
6.04 ± 0.07
6.71 ± 0.14
11.07 ± 0.21
11.04 ± 0.29
8.92 ± 0.28
12.24 ± 0.60
71.39 ± 3.25
78.60 ± 3.41
57.57 ± 2.98
3.99 ± 0.33
88.32 ± 3.34
418.18 ± 17.59
583.49 ± 34.57
value
0.677
0.796
0.706
0.889
0.327
0.84
0.56
0.871
0.526
0.518
0.821
0.777
0.43
rs649446
CC
6.06 ± 0.09
6.84 ± 0.16
11.24 ± 0.24
11.20 ± 0.33
9.46 ± 0.34
12.05 ± 0.55
75.14 ± 3.99
79.96 ± 3.95
56.72 ± 3.32
3.61 ± 0.18
90.91 ± 4.38
404.52 ± 18.16
535.54 ± 20.23
TT
6.06 ± 0.16
6.90 ± 0.32
11.50 ± 0.47
11.65 ± 0.65
10.06 ± 0.73
16.71 ± 2.96
74.87 ± 7.74
83.49 ± 7.86
67.33 ± 7.15
5.78 ± 1.53
108.66 ± 12.90
335.15 ± 26.95
466.10 ± 31.42
TC
5.98 ± 0.07
6.67 ± 0.15
11.01 ± 0.21
10.93 ± 0.29
8.81 ± 0.30
11.38 ± 0.50
70.59 ± 3.32
75.06 ± 3.24
54.06 ± 2.76
3.59 ± 0.23
83.77 ± 3.10
433.37 ± 19.96
599.24 ± 37.91
value
0.765
0.676
0.581
0.567
0.156
0.003
0.655
0.469
0.176
0.006
0.026
0.066
0.096
rs7109266
GG
6.07 ± 0.09
6.86 ± 0.16
11.24 ± 0.24
11.24 ± 0.33
9.48 ± 0.34
12.03 ± 0.55
74.80 ± 3.96
79.68 ± 3.92
56.77 ± 3.29
3.62 ± 0.18
90.40 ± 4.35
402.30 ± 18.07
533.33 ± 20.14
AA
6.07 ± 0.17
6.96 ± 0.33
11.58 ± 0.50
11.79 ± 0.67
10.16 ± 0.77
17.11 ± 3.12
76.19 ± 8.10
84.59 ± 8.20
68.44 ± 7.51
5.98 ± 1.61
109.45 ± 13.52
334.04 ± 28.21
461.60 ± 33.00
GA
5.97 ± 0.07
6.64 ± 0.15
10.99 ± 0.21
10.87 ± 0.29
8.78 ± 0.30
11.37 ± 0.49
70.64 ± 3.31
75.15 ± 3.23
53.93 ± 2.75
3.57 ± 0.23
84.30 ± 3.09
434.69 ± 19.84
601.13 ± 37.71
value
0.601
0.502
0.49
0.401
0.107
0.001
0.656
0.449
0.137
0.003
0.031
0.06
0.078
rs591758
GG
6.05 ± 0.11
6.87 ± 0.21
11.33 ± 0.31
11.24 ± 0.42
9.66 ± 0.46
11.91 ± 0.79
77.66 ± 5.22
78.40 ± 4.75
52.65 ± 3.63
3.46 ± 0.23
89.39 ± 5.7
410.86 ± 23.20
534.33 ± 24.89
CC
5.94 ± 0.11
6.78 ± 0.23
11.11 ± 0.30
11.11 ± 0.41
9.32 ± 0.45
13.43 ± 1.36
73.30 ± 5.06
78.32 ± 4.83
59.57 ± 4.33
4.45 ± 0.70
94.35 ± 6.42
392.34 ± 26.39
525.85 ± 26.71
CG
6.04 ± 0.07
6.70 ± 0.14
11.07 ± 0.21
11.04 ± 0.29
8.91 ± 0.29
11.79 ± 0.48
70.32 ± 3.25
77.56 ± 3.43
56.98 ± 3.00
3.71 ± 0.21
87.12 ± 3.36
419.88 ± 17.95
585.93 ± 35.37
value
0.73
0.775
0.77
0.92
0.343
0.322
0.457
0.987
0.485
0.209
0.57
0.682
0.381
rs586773
AA
6.05 ± 0.11
6.87 ± 0.21
11.33 ± 0.31
11.24 ± 0.42
9.66 ± 0.46
11.91 ± 0.79
77.66 ± 5.22
78.40 ± 4.75
52.65 ± 3.63
3.46 ± 0.23
89.39 ± 5.79
410.86 ± 23.20
534.33 ± 24.89
TT
5.94 ± 0.11
6.78 ± 0.23
11.11 ± 0.30
11.11 ± 0.41
9.32 ± 0.45
13.43 ± 1.36
73.30 ± 5.06
78.32 ± 4.83
59.57 ± 4.33
4.45 ± 0.70
94.35 ± 6.42
392.34 ± 26.39
525.85 ± 26.71
AT
6.04 ± 0.07
6.71 ± 0.14
11.10 ± 0.21
11.09 ± 0.30
8.93 ± 0.29
11.80 ± 0.49
70.25 ± 3.29
77.60 ± 3.46
57.04 ± 3.03
3.73 ± 0.22
86.95 ± 3.39
418.26 ± 18.06
583.80 ± 35.73
value
0.711
0.804
0.798
0.952
0.365
0.33
0.453
0.988
0.484
0.214
0.557
0.713
0.413
rs34408426
AA
6.05 ± 0.11
6.87 ± 0.21
11.33 ± 0.31
11.24 ± 0.42
9.66 ± 0.46
11.91 ± 0.79
77.66 ± 5.22
78.40 ± 4.75
52.65 ± 3.63
3.46 ± 0.23
89.39 ± 5.79
410.86 ± 23.20
534.33 ± 24.89
GG
5.94 ± 0.11
6.78 ± 0.23
11.11 ± 0.30
11.11 ± 0.41
9.32 ± 0.45
13.43 ± 1.36
73.30 ± 5.06
78.32 ± 4.83
59.57 ± 4.33
4.45 ± 0.70
94.35 ± 6.42
392.34 ± 26.39
525.85 ± 26.71
AG
6.03 ± 0.07
6.67 ± 0.13
11.02 ± 0.21
11.00 ± 0.29
8.90 ± 0.29
11.81 ± 0.49
70.71 ± 3.28
77.99 ± 3.46
57.37 ± 3.02
3.71 ± 0.21
87.48 ± 3.38
421.79 ± 18.08
588.64 ± 35.70
value
0.747
0.698
0.694
0.882
0.331
0.332
0.499
0.997
0.471
0.209
0.602
0.646
0.35
rs3019463
CC
6.03 ± 0.11
6.85 ± 0.21
11.30 ± 0.31
11.19 ± 0.42
9.60 ± 0.46
11.91 ± 0.79
77.96 ± 5.25
78.59 ± 4.78
52.63 ± 3.66
3.45 ± 0.24
89.77 ± 5.82
413.23 ± 23.25
537.30 ± 24.89
TT
5.96 ± 0.11
6.82 ± 0.23
11.15 ± 0.31
11.23 ± 0.42
9.40 ± 0.46
13.54 ± 1.39
72.78 ± 5.11
79.20 ± 4.90
60.35 ± 4.41
4.51 ± 0.72
94.20 ± 6.53
381.46 ± 25.95
518.95 ± 26.89
TC
6.02 ± 0.07
6.67 ± 0.14
11.08 ± 0.22
11.00 ± 0.30
8.91 ± 0.29
11.75 ± 0.50
70.74 ± 3.30
78.34 ± 3.50
57.65 ± 3.08
3.70 ± 0.22
87.13 ± 3.38
425.19 ± 18.44
593.35 ± 36.28
value
0.864
0.74
0.847
0.883
0.369
0.278
0.473
0.99
0.41
0.172
0.59
0.39
0.275
. DI30 (early-phase disposition index of insulin secretion) = [InsAUC30/GluAUC30] × ISIM, DI120 (total-phase disposition of insulin secretion) = [InsAUC120/GluAUC120] × ISIM.
