Leptin Modifies the Rat Heart Performance Associated with Mitochondrial Dysfunction Independently of Its Prohypertrophic Effects

<div>Quantification of oxidized lipids in heart homogenates and isolated mitochondria. Levels of oxidized lipids were measured by TBARS methodology in (a) homogenates after 1, 2, 4, or 4 hours of perfusion with/without leptin. 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(b) Isolated mitochondria. (c) Values of TBARS from homogenates and mitochondria were analyzed by Pearson’s test to identify a correlation between variables. R1 = Pearson’s value for control TBARS in the four time points analyzed; R2 = Pearson’s value for leptin TBARS in the four time points analyzed. Note that the correlation is strong and positive for the leptin group.</div>

International Journal of Endocrinology

fig7

Figure 7

Figure 7: Leptin Modifies the Rat Heart Performance Associated with Mitochondrial Dysfunction Independently of Its Prohypertrophic Effects 