Regulatory Effect of 1,25(OH)2D3 on TGF-β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats

Table 4

TGF-β1 mRNA and protein expression.

Groups	n	mRNA	Protein
		TGF-β1	TGF-β1
TGF-β1ov + control	6	2.24 ± 0.20	2.11 ± 0.31
TGF-β1ov + VD	6	1.70 ± 0.16	1.50 ± 0.27
t		5.08	3.54
		<0.01	<0.01
TGF-β1si + control	6	0.93 ± 0.24	0.92 ± 0.41
TGF-β1si + VD	6	0.48 ± 0.19	0.37 ± 0.24
t		3.53	2.82
		<0.01	<0.01

Data are expressed as mean ± standard deviation. TGF-β1ov + control, TGF-β1 overexpression + oil; TGF-β1 ov + VD, TGF-β1 overexpression + 1,25(OH)2D3; TGF-β1si + control, TGF-β1 siRNA + oil; TGF-β1si + VD, TGF-β1 siRNA + 1,25(OH)2D3.