Clinical Features, Treatment, and Surveillance of Hyperparathyroidism-Jaw Tumor Syndrome: An Up-to-Date and Review of the Literature

Table 1

Review of the literature focusing on HPT-JT syndrome.

Author (year)	Kindred ()	pHPT ()	Single-gland pHPT ()	Synchronous multiglandular pHPT ()	Recurrences ()	Parathyroid carcinoma ()	Jaw tumor ()	Renal lesions ()	Uterine lesions ()
Carpten et al. (2002) [7]	14	66	NA	NA	NA	11	30	18	NA
Shattuck et al. (2003) [23]	3	3	NA	NA	NA	3	NA	NA	NA
Howell et al. (2003) [24]	3	7	NA	NA	0	3	0	0	NA
Simonds et al. (2004) [25]	1	4	4	0	0	1	0	0	NA
Cetani et al. (2004) [17]	2	4	3	1	NA	0	0	0	NA
Villablanca et al. (2004) [26]	2	9	7	2	3	0	0	0	NA
Cavaco et al. (2004) [27]	6	9	5	1	0	0	2	2	NA
Howell et al. (2004) [28]	1	2	2	0	NA	0	1	NA	NA
Bradley et al. (2005) [2]	2	9	NA	NA	NA	2	11	0	6
Moon et al. (2005) [29]	1	2	2	0	NA	2	1	NA	NA
Gimm et al. (2006) [30]	1	3	1	1	1	1	NA	NA	NA
Mizusawa et al. (2006) [31]	3	7	6	0	1	1	1	0	0
Aldred et al. (2006) [32]	1	3	3	0	0	0	2	NA	NA
Bradley et al. (2006) [33]	5	5	4	1	NA	0	2	0	1
Juhlin et al. (2006) [34]	1	1	1	NA	NA	0	NA	NA	NA
Guarnieri et al. (2006) [35]	1	4	4	0	1	1	NA	0	2
Kelly et al. (2006) [8]	1	3	2	1	2	2	NA	NA	NA
Yamashita et al. (2007) [36]	1	1	1	0	0	0	1	NA	NA
Cetani et al. (2007) [37]	1	1	1	0	1	0	0	0	NA
Cetani et al. (2007) [38]	2	3	NA	NA	NA	3	NA	NA	NA
Raue et al. (2007) [39]	1	2	1	1	NA	1	1	NA	NA
Cetani et al. (2008) [40]	1	1	1	0	NA	1	0	NA	NA
Sarquis et al. (2008) [41]	3	11	5	6	6	1	1	4	5
Guarnieri et al. (2008) [42]	3	3	3	0	1	3	0	3	3
Howell et al. (2009) [43]	1	1	1	0	0	NA	NA	NA	NA
Silveira et al. (2008) [44]	1	9	3	6	6	1	0	4	5
Schmidt et al. (2009) [45]	1	1	1	0	0	0	1	NA	NA
Rekik et al. (2010) [46]	1	1	1	0	0	0	1	0	1
Panicker et al. (2010) [47]	1	5	NA	NA	NA	0	1	0	1
Veiguela et al. (2010) [48]	1	7	NA	NA	NA	1	3	0	2
Cavaco et al. (2011) [49]	2	2	2	0	1	2	0	0	0
Pichardo-Lowden et al. (2011) [20]	1	1	1	0	1	0	0	1	NA
Frank-Raue et al. (2011) [50]	7	11	9	1	1	3	8	0	2
Cascón et al. (2011) [10]	1	3	NA	NA	NA	0	3	NA	NA
Siu et al. (2011) [51]	2	2	2	0	0	1	0	0	NA
Domingues et al. (2012) [52]	1	1	1	0	0	0	0	0	NA
Guerrouani et al. (2013) [53]	1	1	1	0	NA	0	1	NA	NA
Bricaire et al. (2013) [21]	NA	19	NA	NA	NA	5	4	4	6
Kutcher et al. (2013) [54]	1	1	0	1	0	1	1	1	NA
Ghemigian et al. (2013) [55]	1	3	3	0	0	0	0	NA	NA
Abdulla et al. (2013) [56]	1	1	0	1	1	0	1	NA	NA
Pazienza et al. (2013) [57]	3	7	7	0	0	0	0	1	1
Kong et al. (2014) [58]	1	2	0	2	1	0	1	NA	2
Chiofalo et al. (2014) [59]	1	2	2	0	0	1	1	0	NA
Korpi-Hyövälti et al. (2014) [60]	1	7	NA	NA	NA	2	NA	2	NA
Sriphrapradang et al. (2014) [61]	1	1	1	0	NA	1	1	0	NA
Mehta^a et al. (2014) [62]	7	16	11	5	4	6	2	3	2
Parfitt et al. (2015) [63]	1	1	1	0	0	1	1	0	0
Shibata et al. (2015) [64]	1	1	1	0	1	0	0	0	0
Khadilkar et al. (2015) [65]	4	6	6	0	2	1	2	3	2
Marchiori et al. (2015) [66]	1	1	1	0	0	1	1	0	0
Bellido et al. (2016) [67]	1	1	1	0	0	0	1	NA	NA
Ennazk et al. (2016) [68]	1	1	1	0	0	0	1	NA	NA
Mathews et al. (2016) [69]	1	1	1	0	0	0	1	NA	NA
Mele et al. (2016) [70]	1	1	1	0	1	1	1	NA	0
Piciu et al. (2016) [71]	1	1	1	0	0	0	1	0	1
Guarnieri et al. (2017) [72]	1	3	3	0	0	1	0	0	1
Mamedova et al. (2017) [73]	6	6	6	0	1	4	0	0	0
van der Tuin et al. (2017) [22]	12	32	32	0	NA	5	6	10	1
Dhas et al. (2017) [74]	1	1	1	0	0	0	1	0	1
Rubinstein et al. (2017) [75]	1	1	1	0	0	0	0	0	1
Koikawa et al. (2018) [76]	1	1	1	0	0	0	1	0	1
Bachmeier et al. (2018) [77]	1	1	1	0	0	0	0	0	0
Kapur et al. (2018) [78]	1	1	1	0	NA	1	0	0	0
Ciuffi et al. (2019) [79]	1	1	1	0	NA	1	1	NA	0
Russo et al. (2019) [80]	1	1	1	0	1	1	1	NA	NA
Gill et al. (2019) [81]	13	16	15	1	3	4	1	NA	NA
Iacobone et al. (2019) [82]	5	20	19	1	6	3	2	1	14
Total (%)	154	365	198 (86.1%)	32 (13.9%)	46 (20%)	84 (23%)	104 (28.4%)	57 (15.6%)	60 (45.1%)

^aSome cases have been previously included in Carpten et al. [7]. NA = not available; pHPT =  primary hyperparathyroidism.