Preoperative and Postoperative Bone Mineral Density Change and Risk Factor Analysis in Patients with a GH-Secreting Pituitary Adenoma

Table 1

Basic information of the GH-secreting pituitary adenoma group and the nonfunctioning pituitary adenoma group.

	GH-secreting pituitary adenoma	Nonfunctioning pituitary adenoma
N	39	29	—
Gender (M/F)	19/20	15/14	—
Age (years)	43.74 ± 10.33	49.14 ± 16.00	0.120
BMI (kg/m^2)	26.03 ± 4.57	24.69 ± 2.73	0.292
Disease duration (months)	72.15 ± 49.33	17.97 ± 34.84	<0.001
Adenoma size (mm)	15.97 ± 6.87	26.43 ± 9.63	<0.001
GH (ng/mL)	33.49 ± 48.75	0.80 ± 1.77	<0.001
IGF-1 (ng/mL)	855.00 ± 261.91	168.52 ± 81.14	<0.001
T3 (ng/mL)	1.37 ± 1.47	0.97 ± 0.22	0.109
T4 (ng/mL)	7.64 ± 1.70	7.45 ± 1.64	0.660
FT3 (pg/mL)	3.25 ± 0.70	2.65 ± 0.45	<0.001
FT4 (pg/mL)	1.17 ± 0.21	1.06 ± 0.20	0.041
TSH (mU/L)	1.55 ± 1.03	2.33 ± 2.59	0.143
F (ng/mL)	10.12 ± 5.22	12.43 ± 6.29	0.130
ACTH (pg/mL)	38.12 ± 23.96	26.39 ± 18.20	0.095
PRL (ng/mL)	21.34 ± 40.13	23.30 ± 20.03	0.796
T (ng/mL)	1.41 ± 1.07	1.75 ± 1.62	0.740
P (ng/mL)	1.30 ± 2.78	0.59 ± 0.41	0.237
E2 (pg/mL)	60.89 ± 121.74	103.63 ± 263.72	0.497
LH (IU/L)	10.82 ± 10.74	8.66 ± 8.04	0.303
FSH (IU/L)	22.77 ± 24.69	21.52 ± 22.67	0.860
Ca (mmol/L)	2.36 ± 0.18	2.33 ± 0.10	0.403
P (mmol/L)	1.55 ± 0.22	1.26 ± 0.13	<0.001

BMI: body mass index; GH: growth hormone; IGF-1: insulin-like growth factor-1; T3: triiodothyronine; T4: thyroxine; TSH: thyroid-stimulating hormone; F: cortisol; ACTH: adrenocorticotropic hormone; PRL: prolactin; T: testosterone; P: progestogen; E2: oestradiol; LH: luteinizing hormone; FSH: follicle-stimulating hormone; Ca: calcium; P: phosphorus.