Preoperative and Postoperative Bone Mineral Density Change and Risk Factor Analysis in Patients with a GH-Secreting Pituitary Adenoma

Table 4

Correlation analysis of clinical data and the BMD Z score.

		L1	L2	L3	L4	L1–L4	L2–L4	Femoral neck	Ward triangle	Trochanter	Total hip
Age (years)	r	−0.110	−0.125	−0.156	−0.125	−0.123	−0.131	−0.017	0.068	0.056	−0.039
		0.506	0.449	0.343	0.447	0.456	0.425	0.919	0.682	0.735	0.816
BMI (kg/m^2)	r	−0.049	−0.048	0.069	−0.034	−0.014	−0.023	0.082	−0.102	0.054	0.235
		0.768	0.772	0.675	0.835	0.931	0.887	0.618	0.535	0.742	0.150
Disease duration (months)	R	−0.389	−0.370	−0.371	−0.371	−0.413	−0.393	−0.280	−0.276	−0.319	−0.324
		0.014	0.021	0.020	0.020	0.009	0.013	0.084	0.088	0.048	0.044
Adenoma size (mm)	r	0.070	0.183	0.144	0.147	0.139	0.155	0.102	0.120	0.104	0.114
		0.670	0.264	0.383	0.371	0.400	0.346	0.535	0.466	0.528	0.488
GH (ng/mL)	r	0.240	0.272	0.186	0.178	0.229	0.214	0.194	0.101	0.191	0.192
		0.140	0.094	0.257	0.277	0.161	0.190	0.236	0.541	0.245	0.241
IGF-1 (ng/mL)	r	0.021	0.097	0.097	0.096	0.086	0.106	0.191	0.041	0.133	0.193
		0.897	0.556	0.559	0.563	0.603	0.522	0.244	0.802	0.421	0.240
IGF-1 burden (ng/mL  month)	r	−0.326	−0.273	−0.277	−0.267	−0.319	−0.298	−0.150	−0.197	−0.213	−0.174
		0.042	0.093	0.088	0.100	0.048	0.066	0.362	0.230	0.194	0.291
FT3 (pg/mL)	r	−0.006	−0.077	−0.066	−0.057	−0.072	−0.073	−0.215	−0.231	−0.128	−0.117
		0.970	0.643	0.692	0.729	0.665	0.659	0.188	0.157	0.436	0.477
FT4 (pg/mL)	r	−0.195	−0.176	−0.081	−0.096	−0.124	−0.118	−0.100	−0.057	−0.095	−0.107
		0.234	0.283	0.623	0.559	0.452	0.474	0.543	0.728	0.564	0.518
PRL (ng/mL)	r	−0.129	−0.184	−0.219	−0.240	−0.227	−0.234	−0.329	−0.255	−0.361	−0.313
		0.435	0.263	0.180	0.142	0.164	0.151	0.041	0.117	0.024	0.053
Ca (mmol/L)	r	0.140	0.057	0.038	0.001	0.083	0.054	0.230	0.250	0.233	0.136
		0.396	0.730	0.819	0.995	0.614	0.746	0.159	0.124	0.154	0.411
P (mmol/L)	r	0.077	0.048	0.040	−0.039	0.024	0.015	−0.015	−0.022	−0.025	0.042
		0.641	0.771	0.808	0.812	0.883	0.929	0.929	0.897	0.878	0.801

BMI: body mass index; GH: growth hormone; IGF-1: insulin-like growth factor-1; FT3: free triiodothyronine; FT4: free thyroxine; PRL: prolactin; Ca: calcium; P: phosphorus.