A Possible Mechanism of Metformin in Improving Insulin Resistance in Diabetic Rat Models

Table 2

Biochemical characteristics after administration of metformin.

Parameters	CON	DM	DM + MET
Body weight (g)	482.56 ± 40.12	376.28 ± 44.87^a	336.43 ± 38.79^ab
FPG (mmol/L)	4.67 ± 0.86	17.49 ± 2.77^aa	14.26 ± 5.72^ab
FIN (m IU/L)	7.11 ± 0.79	12.58 ± 0.93^a	10.75 ± 0.39^ab
TG (mmol/L)	1.38 ± 0.58	3.97 ± 1.03^a	3.79 ± 0.87^a
TC (mmol/L)	2.07 ± 0.28	10.46 ± 3.62^aa	3.08 ± 0.98^ab
LDL-C (mmol/L)	0.65 ± 0.21	6.83 ± 0.24^a	0.91 ± 0.34^ab
HDL-C (mmol/L)	2.12 ± 0.41	1.08 ± 0.17^a	1.46 ± 0.25^ab
TBAs (μmol/L)	30.66 ± 1.93	102.75 ± 5.18^a	77.63 ± 3.28^ab
HOMA-IR	1.48 ± 0.44	9.78 ± 2.27^a	6.81 ± 2.98^ab

The body weight (BW), fasting plasma glucose (FPG), fasting insulin (FIN), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), total bile acids (TBAs), and triglycerides (TG) levels were analyzed using cobas 8000 automatic biochemistry analyzer. HOMA-IR = [FBG(mmol/L) × FINS(μU/mL)]/22.5. Data are expressed as mean ± SEM. ^a, ^aa vs. CON rats. ^b vs. DM rats. CON group: control rats group; DM group: HFD/STZ-induced diabetic rats group; DM + METF rats: HFD/STZ-induced diabetic rats supplemented with metformin treatment.