MC4R Single Nucleotide Polymorphisms Were Associated with Metabolically Healthy and Unhealthy Obesity in Chinese Northern Han Populations
Table 1
Demographic and clinical data of all participants.
Traits
Obesity
Normal weight
Obesity
MUHO
MHO
Normal weight
MUH-NW
MH-NW
N
496
300
196
604
303
301
Male/female
262/234
150/150
112/84
306/298
144/159
162/139
0.86
0.47
0.11
0.08
Age (years)
46.6 ± 11.9
47.7 ± 12.5
44.8 ± 12.6
46.8 ± 11.4
48.3 ± 11.4
45.2 ± 10.9
0.16
0.08
0.09
0.16
BMI (kg/m2)
32.5 ± 3.2
32.7 ± 3.9
32.2 ± 2.8
22.6 ± 1.6
23.1 ± 1.8
22.1 ± 1.7
<0.01
<0.01
0.06
0.19
Height (cm)
163.8 ± 8.8
164.6 ± 8.8
162.7 ± 8.5
164.9 ± 9.0
164.8 ± 8.6
165.1 ± 9.8
0.06
0.51
0.05
0.39
WC (cm)
99.9 ± 9.6
101.2 ± 10.0
98.0 ± 8.0
80.5 ± 7.4
83.3 ± 7.0
77.6 ± 7.2
<0.01
<0.01
0.90
0.33
Weight (kg)
87.8 ± 17.7
89.4 ± 17.2
85.3 ± 12.0
62.1 ± 8.6
62.9 ± 8.6
61.2 ± 10.1
<0.01
<0.01
<0.01
<0.01
DBP (mmHg)
131.9 ± 18.2
136.0 ± 19.0
125.6 ± 15.3
118.4 ± 15.6
123.5 ± 17.7
113.3 ± 10.9
<0.01
<0.01
0.01
<0.01
SBP (mmHg)
84.0 ± 12.2
86.0 ± 12.7
80.9 ± 11.5
75.7 ± 10.3
79.2 ± 11.5
72.1 ± 7.8
<0.01
<0.01
<0.01
<0.01
FBG (mmol/L)
6.9 ± 1.3
6.2 ± 1.6
5.4 ± 1.0
5.5 ± 1.6
5.9 ± 1.6
5.0 ± 0.4
<0.01
<0.01
<0.01
<0.01
TG (mmol/L)
2.0 ± 1.5
2.4 ± 1.7
1.4 ± 0.6
1.7 ± 1.5
2.3 ± 1.9
1.1 ± 0.8
<0.01
<0.01
<0.01
0.08
HDL (mmol/L)
1.3 ± 0.5
1.1 ± 0.3
1.6 ± 0.8
1.3 ± 0.3
1.2 ± 0.3
1.5 ± 0.4
<0.01
<0.01
0.09
<0.01
TC (mmol/L)
4.9 ± 1.0
4.9 ± 1.0
4.9 ± 0.9
4.9 ± 1.0
5.0 ± 1.0
4.8 ± 0.9
0.05
0.046
0.46
<0.01
LDL (mmol/L)
3.1 ± 0.8
3.1 ± 0.8
3.1 ± 0.8
3.0 ± 0.8
3.1 ± 0.8
2.9 ± 0.7
<0.01
0.032
0.06
0.19
, OB vs. NW; , MUHO vs. MH-NW; , MUHO vs. MHO; , MUH-NW vs MH-NW. MUH-NW, metabolic unhealthy normal weight; MH-NW, metabolic healthy normal weight; MUHO, metabolically unhealthy obesity; MHO, metabolically healthy obesity; BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose; HDL-C, high-density lipoprotein; TG, triglyceride; LDL, low-density lipoprotein; TC, total cholesterol. Data were expressed by mean ± standard deviation.
