MC4R Single Nucleotide Polymorphisms Were Associated with Metabolically Healthy and Unhealthy Obesity in Chinese Northern Han Populations

Table 2

Allelic and genotypic association of SNPs in the case-control study using logistic regression.

SNPs	Allele	Allele gene				Genotype count
	1/2	1/2	1/2	OR		11/12/22	11/12/22	OR
		Case	Control	(95% CI)		Case	Control	(95% CI)
Obesity: normal weight
rs2331841	A/G	276/842	198/722	1.21 (0.98, 1.50)	0.07	38/200/321	18/162/280	1.38 (1.03, 1.85)	0.032
rs6567160	C/T	262/858	193/729	1.16 (0.94, 1.44)	0.17	33/196/331	17/159/285	1.30 (0.96, 1.77)	0.089
rs571312	A/C	259/859	189/725	1.16 (0.94, 1.44)	0.17	32/195/332	17/155/285	1.28 (0.94, 1.73)	0.12
rs17782313	C/T	259/859	193/727	1.14 (0.92, 1.41)	0.22	34/191/334	18/157/285	1.28 (0.95, 1.72)	0.11
rs12970134	A/G	228/888	180/742	1.07 (0.86, 1.34)	0.55	24/180/354	11/158/292	1.37 (0.95, 1.98)	0.093
rs11872992	A/G	233/887	207/713	0.90 (0.73, 1.11)	0.31	32/169/359	24/159/277	1.00 (0.76, 1.32)	0.99
Obesity: metabolic healthy normal weight (MH-NW)
rs2331841	A/G	234/676	120/450	1.32 (1.02, 1.69)	0.034	31/172/252	12/96/177	1.35 (1.92, 0.96)	0.08
rs6567160	C/T	224/686	118/454	1.27 (0.98, 1.64)	0.065	27/170/258	11/96/179	1.32 (0.92, 1.89)	0.14
rs571312	A/C	220/686	116/452	1.27 (0.98, 1.64)	0.074	26/168/259	11/94/179	1.28 (0.89, 1.92)	0.17
rs17782313	C/T	223/687	118/452	1.25 (0.97, 1.61)	0.079	28/167/260	12/94/179	1.28 (0.90, 1.82)	0.17
rs12970134	A/G	196/714	115/457	1.10 (0.85, 1.43)	0.47	20/156/279	8/99/179	1.28 (0.84, 1.96)	0.25
rs11872992	A/G	201/709	123/447	1.02 (0.79, 1.30)	0.89	30/141/284	11/101/173	1.27 (0.88, 1.82)	0.2
Metabolically unhealthy obesity (MUHO): metabolic healthy normal weight (MH-NW)
rs2331841	A/G	156/404	120/450	1.49 (1.14, 1.96)	0.005 ^a	25/106/149	12/96/177	1.64 (1.14, 2.38)	0.008
rs6567160	C/T	149/411	118/454	1.45 (1.09, 1.92)	0.011 ^a	21/107/152	11/96/179	1.54 (1.05, 2.27)	0.026
rs571312	A/C	147/413	116/452	1.43 (1.08, 1.89)	0.013 ^a	20/107/153	11/94/179	1.49 (1.02, 2.22)	0.041
rs17782313	C/T	148/412	118/452	1.41 (1.06, 1.67)	0.015 ^a	22/104/154	12/94/179	1.52 (1.04, 2.17)	0.03
rs12970134	A/G	131/429	115/457	1.25 (0.93, 1.67)	0.14	17/97/166	8/99/179	1.56 (1.01, 2.48)	0.048
rs11872992	A/G	117/443	123/447	0.93 (0.70, 1.23)	0.61	17/83/180	11/101/173	1.18 (0.79, 1.75)	0.43
Metabolically unhealthy obesity (MUHO): metabolically healthy obesity (MHO)
rs2331841	A/G	78/272	156/404	1.39 (1.02, 1.92)	0.039	6/66/103	25/106/149	1.75 (1.10, 2.78)	0.017
rs6567160	C/T	75/275	149/411	1.37 (0.99, 1.89)	0.056	6/63/106	21/107/152	1.56 (0.98, 2.50)	0.052
rs571312	A/C	73/273	147/413	1.36 (0.98, 1.89)	0.063	6/61/106	20/107/153	1.52 (0.95, 2.44)	0.078
rs17782313	C/T	75/275	148/412	1.36 (0.98, 1.87)	0.065	6/63/106	22/104/154	1.59 (0.99, 2.56)	0.044
rs12970134	A/G	65/285	131/429	1.37 (0.97, 1.92)	0.070	3/59/113	17/97/166	1.96 (1.05, 3.67)	0.027
rs11872992	A/G	84/266	117/443	0.84 (0.62, 1.14)	0.27	13/58/104	17/83/180	0.87 (0.59, 1.078)	0.36

^aRemain significant after false discovery rate (FDR) analysis.