MC4R Single Nucleotide Polymorphisms Were Associated with Metabolically Healthy and Unhealthy Obesity in Chinese Northern Han Populations

Table 3

Dominant and recessive model association of SNPs in the case-control study by logistic regression analysis.

SNPs	Allele	Dominant model				Recessive model
	1/2	11 + 12/22	11 + 12/22	OR		11/12 + 22	11/12 + 22	OR
		Case	Control	(95% CI)		Case	Control	(95% CI)
Obesity: normal weight
rs2331841	A/G	238/321	180/280	1.18 (0.91, 1.52)	0.21	38/521	18/442	1.84 (1.03, 3.28)	0.039
rs6567160	C/T	229/331	176/285	1.13 (0.87, 1.46)	0.35	33/527	17/444	1.66 (0.91, 3.03)	0.099
rs571312	A/C	227/332	172/285	1.14 (0.88, 1.47)	0.32	32/527	17/440	1.58 (0.86, 2.90)	0.14
rs17782313	C/T	225/334	175/285	1.10 (0.86, 1.43)	0.44	34/525	18/442	1.61 (0.89, 2.90)	0.11
rs12970134	A/G	204/354	169/292	1.00 (0.77, 1.30)	0.98	24/534	11/450	1.92 (0.92, 3.98)	0.081
rs1187299	A/G	201/359	183/277	0.84 (0.65, 1.08)	0.17	32/528	24/436	1.07 (0.62, 1.86)	0.8
Obesity: metabolic healthy normal weight (MH-NW)
rs2331841	A/G	203/252	108/177	1.33 (0.99, 1.82)	0.059	31/424	12/273	1.69 (0.85, 3.33)	0.13
rs6567160	C/T	197/258	107/179	1.30 (0.95, 1.75)	0.099	27/428	11/275	1.59 (0.78, 3.23)	0.2
rs571312	A/C	194/259	105/179	1.30 (0.95, 1.75)	0.1	26/427	11/273	1.52 (0.74, 3.13)	0.25
rs17782313	C/T	195/260	106/179	1.28 (0.94, 1.75)	0.11	28/427	12/273	1.52 (0.75, 3.03)	0.25
rs12970134	A/G	176/279	107/179	1.06 (0.78, 1.45)	0.7	20/435	8/278	1.62 (0.70, 3.70)	0.25
rs11872992	A/G	171/284	112/173	0.92 (0.68, 1.25)	0.59	30/425	11/274	1.69 (0.83, 3.45)	0.14
Metabolically unhealthy obesity (MUHO): metabolic healthy normal weight (MH-NW)
rs2331841	A/G	131/149	108/177	1.49 (1.06, 2.08)	0.019	25/255	12/273	2.38 (1.16, 4.76)	0.017
rs6567160	C/T	128/152	107/179	1.45 (1.04, 2.04)	0.028	21/259	11/275	2.12 (1.01, 4.54)	0.049
rs571312	A/C	127/153	105/179	1.47 (1.04, 2.04)	0.029	20/260	11/273	2.04 (0.93, 4.17)	0.078
rs17782313	C/T	126/154	106/179	1.43 (1.02, 2.00)	0.039	22/258	12/273	2.04 (0.98, 4.17)	0.057
rs12970134	A/G	114/166	107/179	1.18 (0.83, 1.64)	0.36	17/263	8/278	2.32 (0.99, 5.56)	0.053
rs11872992	A/G	100/180	112/173	0.83 (0.58, 1.16)	0.28	17/263	11/274	1.52 (0.69, 3.33)	0.3
Metabolically unhealthy obesity (MUHO): metabolically healthy obesity (MHO)
rs2331841	A/G	131/149	72/103	1.31 (0.89, 1.93)	0.07	25/255	6/169	2.93 (1.17, 7.35)	0.022
rs6567160	C/T	128/152	69/106	1.35 (0.91, 1.97)	0.14	21/259	6/169	2.37 (0.93, 6.05)	0.07
rs571312	A/C	127/153	67/106	1.35 (0.91, 1.99)	0.13	20/260	6/167	2.15 (0.84, 5.51)	0.11
rs17782313	C/T	126/154	69/106	1.30 (0.88, 1.92)	0.18	22/258	6/169	2.48 (0.98, 6.28)	0.056
rs12970134	A/G	114/166	62/113	1.27 (0.85, 1.88)	0.24	17/263	3/172	3.98 (1.14, 13.89)	0.030
rs11872992	A/G	100/180	71/104	0.82 (0.55, 1.21)	0.32	17/263	13/162	0.74 (0.35, 1.57)	0.43