Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China
Table 3
Prevalence of comorbidities in different CS patient etiologies [ (%)].
Comorbidities
ACTH-dependent
ACTH-independent
Overall
CD
EAS
Uncertain causea
Total
ACA
ACCa
BMAH
PPNAD
Total
()
()
()
()
()
()
()
()
()
()
Hypertension
749 (72.0)∆
75 (76.5)
19 (95.0)
843 (72.8)
214 (61.8)
10 (62.5)
85 (83.3)∆
25 (83.3)
334 (67.6)#
1177 (71.2)
Diabetes mellitus
424 (40.8)∆
60 (61.2) ∆†‡
12 (60.0)
496 (42.8)
92 (26.6)
6 (37.5)
44 (43.1)∆‡
4 (13.3)
146 (29.6)#
642 (38.9)
Impaired glucose tolerance
148 (14.2)
16 (16.3)
5 (25.0)
169 (14.6)
41 (11.8)
1 (6.3)
16 (15.7)
8 (26.7)
66 (13.4)
235 (14.2)
Osteoporosis without fractures
263 (25.3)∆
17 (17.3)
5 (25.0)
285 (24.6)
40 (11.6)
1 (6.3)
16 (15.7)
7 (23.3)
64 (13.0)
349 (21.1)
Osteoporotic fractures
178 (17.1)Ơ
28 (28.6)Ơ
10 (50.0)
216 (18.7)
31 (9.0)
2 (12.5)
5 (4.9)
8 (26.7)Ơ
46 (9.3)
262 (15.9)
Dyslipidemia
435 (41.8)∆
39 (39.8)∆
10 (0.5)
484 (41.8)
86 (24.9)
3 (18.8)
38 (37.3)
12 (40.0)
139 (28.1)#
623 (37.7)
Fatty liver
285 (27.4)∆
27 (27.6)∆
8 (40.0)
320 (27.6)
50 (14.5)
0 (0.0)
31 (30.4)
9 (30.0)
90 (18.2)#
410 (24.8)
Hypokalemia
132 (12.7)
51 (52.0)∆†‡
10 (50.0)
193 (16.7)
28 (8.1)
2 (12.5)
8 (7.8)
2 (6.7)
40 (8.1)#
233 (14.1)
Ischemic heart disease
30 (2.9)
5 (5.1)
0 (0.0)
35 (3.0)
8 (2.3)
0 (0.0)
7 (6.9)
0 (0.0)
15 (3.0)
50 (3.0)
Cerebrovascular disease
43 (4.1)
4 (4.1)
2 (10.0)
49 (4.2)
12 (3.5)
1 (6.3)
14 (13.7)∆
1 (3.3)
28 (5.7)
77 (4.7)
Psychiatric disorders
34 (3.3)
4 (4.1)
2 (10.0)
40 (3.5)
8 (2.3)
1 (6.3)
3 (2.9)
2 (6.7)
14 (2.8)
54 (3.3)
versus CD; ∆ versus ACA; † versus BMAH; ‡ versus PPNAD; # versus ACTH-dependent CS. aACC and ACTH-dependent CS with uncertain cause were excluded from intergroup comparisons because of the small sample size and ambiguous etiology, respectively.
