Delayed Bone Age Might Accelerate the Response to Human Growth Hormone Treatment in Small for Gestational Age Children with Short Stature
Table 1
Clinical and laboratory characteristics of study patients.
Patient no.
Total
Males
Females
value
27
10
17
Gestational age (months)
37.7 ± 2.7
37.3 ± 3.7
38.0 ± 2.0
0.208
Birth weight (g)
2239.3 ± 447.0
2298.0 ± 470.5
2204.7 ± 443.6
0.683
Age (years)
7.2 ± 1.9
7.3 ± 2.0
7.1 ± 2.0
0.862
BMI (kg/m2, Z-score)
−0.51 ± 0.92
−0.78 ± 0.89
−0.35 ± 0.93
0.988
Height SDS
−2.53 ± 0.44
−2.52 ± 0.30
−2.53 ± 0.51
0.349
BA (years)
5.0 ± 2.7
3.8 ± 2.1
5.6 ± 2.9
0.160
CA-BA (years)
2.2 ± 1.5
3.4 ± 1.0
1.4 ± 1.3
0.080
BA/CA
0.66 ± 0.24
0.50 ± 0.16
0.75 ± 0.23
0.110
IGF-1 SDS
−1.06 ± 0.86
−1.21 ± 0.83
−0.96 ± 0.89
0.596
rhGH (IU/kg/day)
0.14 ± 0.05
0.14 ± 0.03
0.16 ± 0.04
0.434
GHD (no., %)
14 (51.9%)
7 (70%)
7 (41.2%)
No.: number; BA, bone age; CA-BA, differences between bone age and chronological age; BA/CA, bone age to chronological age ratio; rhGH, recombinant human growth hormone; GHD, growth hormone deficiency.
