Effect of Denosumab on Glucose Homeostasis in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors: A Pilot Study

Figure 1

Correlations between serum CTX levels and OGTT-derived indexes of insulin sensitivity in postmenopausal breast cancer women treated with AIs at baseline and 1 month after 60 mg Dmab administration. At baseline evaluation, no significant correlation could be detected between serum CTX levels and both insulin AUC (a) and Matsuda Index (b) while 1 month after Dmab injection, suppressed CTX levels positively correlated with insulin AUC (c) and negatively with Matsuda Index (d). Continuous line, linear regression; dashed lines, 95% confidence interval. AUC, area under the curve of serum insulin levels after 75 g oral glucose load; CTX, C-terminal telopeptide of type 1 collagen.

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