Germline Mutation in <i>KIF1Bβ</i> Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma

<div>Representative ultrastructural micrographs of a pheochromocytoma bearing the <i>KIF1Bβ</i> mutation (a, b) in comparison with a wild-type tumor (c). Gene mutation is associated with the occurrence of numerous swollen mitochondria (dashed arrows) with reduction of cristae and matrix clearing. Several autophagic vacuoles (black arrows) containing remnants of organelles, including mitochondria (a) can also be seen. Magnification: x12,000.</div>

International Journal of Endocrinology

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Figure 3: Germline Mutation in <i>KIF1Bβ</i> Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma 

Figure 3 | Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma 