p.Gln318X and p.Val281Leu as the Major Variants of CYP21A2 Gene in Children with Idiopathic Premature Pubarche

Figure 2

Binding sites of normal (left side) and mutant (right side) of p.Val281Leu in CYP21A2 protein predicted by 3DLigandSite server. Average distance ranges from 0–1.00 for each residue, which it was affected by this substitution as shown in red box; a new binding site, Lys120, is added based on this prediction.