Islet Stellate Cells Regulate Insulin Secretion via Wnt5a in Min6 Cells

Figure 1

Insulin secretion in islets is increased by coculture with ISCs. (a) Islets were isolated from db/m mice, and ISCs outgrowth from the islets was analysed by microscopy (scale bars = 50 μm). (b) Compared with islets cultured alone, islets cocultured with ISCs isolated from db/m mice showed significantly increased insulin secretion in vitro. The data are expressed as the mean ± SE (n = 3), , , vs. islets cultured alone.

(a)

(b)