Islet Stellate Cells Regulate Insulin Secretion via Wnt5a in Min6 Cells

Figure 5

Wnt5a increases insulin secretion from Min6 cells. (a, b) Compared with islets cultured alone, islets cocultured with ISCs or Wnt5a exhibited significantly increased insulin secretion. The data are expressed as the mean ± SE (n = 3); , , vs. islets cultured alone. (c) Compared with Min6 cells cultured alone, Min6 cells cocultured with ISCs or Wnt5a exhibited significantly increased insulin secretion. (d) Apoptosis assays of Min6 cells from the cytokine-induced and control groups. (e) Proliferation assays of Min6 cells from the cytokine-induced and control groups. The data are expressed as the means ± SE (n = 3); , , vs. Min6 cells cultured alone.

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