Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study

Table 1

Clinicopathological characteristics of T2DM patients and controls.

Characteristic	T2DM (n = 300)	Control (n = 100)	value
Age (years)	40.33 ± 9.76	35.29 ± 7.96	<0.0001
BMI (kg/m^2)	28.8 ± 5.22	24.83 ± 2.33	<0.0001
PPG (mg/dl)	208.5 ± 48.49	135 ± 13.02	<0.0001
FPG (mg/dl)	140 ± 35.64	90.22 ± 7.11	<0.0001
FPI	9.6 ± 1.35	8.66 ± 0.71	<0.0001
HbA1c	7.12 ± 1.03	5.75 ± 0.54	<0.0001
T-cholesterol (mg/dl)	245.58 ± 15.14	152.63 ± 18.82	<0.0001
Systolic BP (mmHg)	146.79 ± 17.05	106.07 ± 10.39	<0.0001
Diastolic BP (mmHg)	102.87 ± 16.19	75.85 ± 10.91	<0.0001
Triglycerides(mg/dl)	356.32 ± 100.48	140.98 ± 5.52	<0.0001
HDL-C (mg/dl)	45.89 ± 11.47	46.21 ± 8.7	0.7985
LDL-C (mg/dl)	194.60 ± 27.38	106.42 ± 19.92	<0.0001
Gender (male/female)	177/123	68/32	0.11
Family history (yes/no)	131/169	39/61	0.414
Smoking (yes/no)	139/161	15/85	<0.0001
Alcohol consumption (yes/no)	140/160	10/90	<0.0001

Data are presented as mean ± SD except gender, family history, smoking, and alcohol consumption. values were calculated by Student’s t-test, while the Chi-square test was used for gender, family history, smoking, and alcohol consumption. Significant at . BMI: body mass index; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HbA1c: haemoglobin A_1c HDL: high-density lipoprotein; LDL: low-density lipoprotein.