Research Article
Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study
Table 7
Combined effect of KCNJ11 + KCNQ1 genotypes on clinicopathological parameters.
| | Parameters | Genotype variables KCNJ11 + KCNQ1 | Mean ± SD | value |
| | BMI | (AA + AA) | 27.79 ± 4.47 | 0.069 | | (AG + AC) | 29.24 ± 5.07 | | (GG + CC) | 25.99 ± 3.37 | | (AG + CC) | 27.88 ± 5.49 | | (AG + AA) | 27.45 ± 4.8 | | (GG + AA) | 27.47 ± 5.00 |
| | PPG | (AA + AA) | 177.41 ± 53.14 | 0.003 | | (AG + AC) | 193.88 ± 39.85 | | (GG + CC) | 177.59 ± 47.63 | | (AG + CC) | 210.09 ± 68.61 | | (AG + AA) | 184.07 ± 46.72 | | (GG + AA) | 196.50 ± 62.67 |
| | FPG | (AA + AA) | 121.12 ± 40.06 | 0.030 | | (AG + AC) | 132.55 ± 38.45 | | (GG + CC) | 120.45 ± 26.15 | | (AG + CC) | 132.07 ± 43.79 | | (AG + AA) | 122.18 ± 30.65 | | (GG + AA) | 134.38 ± 42.72 |
| | FPI | (AA + AA) | 9.04 ± 1.20 | 0.29 | | (AG + AC) | 9.54 ± 1.41 | | (GG + CC) | 8.98 ± 1.14 | | (AG + CC) | 9.42 ± 1.24 | | (AG + AA) | 9.39 ± 1.23 | | (GG + AA) | 9.42 ± 1.40 |
| | HbA1C | (AA + AA) | 6.57 ± 1.10 | 0.238 | | (AG + AC) | 6.94 ± 1.12 | | (GG + CC) | 6.59 ± 0.93 | | (AG + CC) | 6.79 ± 1.08 | | (AG + AA) | 6.74 ± 1.08 | | (GG + AA) | 6.92 ± 1.24 |
| | Cholesterol | (AA + AA) | 211.97 ± 46.99 | 0.009 | | (AG + AC) | 230.80 ± 38.24 | | (GG + CC) | 218.63 ± 52.46 | | (AG + CC) | 234.34 ± 36.31 | | (AG + AA) | 216.69 ± 44.70 | | (GG + AA) | 223.84 ± 45.10 |
| | HDL | (AA + AA) | 46.69 ± 9.18 | 0.117 | | (AG + AC) | 45.03 ± 10.48 | | (GG + CC) | 47.72 ± 9.52 | | (AG + CC) | 45.39 ± 12.97 | | (AG + AA) | 46.80 ± 10.20 | | (GG + AA) | 44.23 ± 12.98 |
| | LDL | (AA + AA) | 159.88 ± 48.49 | 0.005 | | (AG + AC) | 182.14 ± 41.31 | | (GG + CC) | 170.90 ± 53.74 | | (AG + CC) | 183.42 ± 41.27 | | (AG + AA) | 166.94 ± 47.61 | | (GG + AA) | 176.92 ± 45.11 |
| | Triglycerides | (AA + AA) | 277.84 ± 133.61 | 0.45 | | (AG + AC) | 317.14 ± 125.36 | | (GG + CC) | 274.09 ± 109.46 | | (AG + CC) | 336.88 ± 123.27 | | (AG + AA) | 289.20 ± 128.33 | | (GG + AA) | 313.30 ± 120.98 |
| | Systolic BP | (AA + AA) | 132.08 ± 24.79 | 0.28 | | (AG + AC) | 138.63 ± 21.56 | | (GG + CC) | 133.36 ± 25.96 | | (AG + CC) | 141.96 ± 22.52 | | (AG + AA) | 134.87 ± 24.31 | | (GG + AA) | 138.53 ± 23.17 |
| | Diastolic BP | (AA + AA) | 93.84 ± 22.38 | 0.010 | | (AG + AC) | 100.10 ± 17.54 | | (GG + CC) | 95.45 ± 21.38 | | (AG + CC) | 100.39 ± 16.99 | | (AG + AA) | 93.22 ± 19.21 | | (GG + AA) | 94.87 ± 15.87 |
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