DPP4 Activities Are Associated with Osteopenia/Osteoporosis and Fracture Risk in Newly Diagnosed Type 2 Diabetes
Table 1
Comparison of baseline characteristics by bone status across cohorts with newly diagnosed type 2 diabetes.
Variables
Normal (n = 57)
Osteopenia (n = 64)
Osteoporosis (n = 26)
value
Female, n (%)
20 (35.1)
29 (45.3)
17 (65.4)
0.02
Smoking, n (%)
20 (35.1)
27 (42.2)
7 (26.9)
0.38
Age (years)
53.4 ± 3.2
55.7 ± 4.1
57.6 ± 5.0
<0.01
BMI (kg/m2)
25.3 ± 2.1
25.0 ± 1.7
24.9 ± 1.7
0.66
HbA1c (%)
6.5 ± 0.4
6.6 ± 0.4
6.6 ± 0.4
0.85
FBG (mmol/L)
8.2 ± 1.4
8.2 ± 1.4
8.1 ± 1.1
0.96
HOMA-IR
5.4 ± 1.6
5.4 ± 1.2
5.4 ± 1.1
0.98
HOMA-IS
69.2 ± 25.0
71.8 ± 30.7
71.7 ± 23.3
0.86
TG (mmol/L)
1.6 ± 0.7
1.7 ± 1.0
1.6 ± 0.7
0.75
TC (mmol/L)
4.7 ± 1.2
5.0 ± 1.1
4.7 ± 1.1
0.42
LDL (mmol/L)
2.8 ± 0.7
2.8 ± 0.6
2.6 ± 0.7
0.51
HDL (mmol/L)
1.3 ± 0.3
1.3 ± 0.3
1.3 ± 0.3
0.83
BUN (mmol/L)
5.1 ± 1.5
5.1 ± 1.4
5.4 ± 1.9
0.71
Cr (μmol/L)
73 ± 23
76 ± 20
70 ± 18
0.44
UA (μmol/L)
409 ± 80
409 ± 78
416 ± 85
0.90
DPP4 activity (nmol/min/ml)
7.3 ± 0.8
7.5 ± 0.9
7.7 ± 0.8
0.07
Data are presented as mean ± SD or percentages. BMI, body mass index; HbA1c: hemoglobin A1c; FBG: fasting blood glucose; HOMA-IR: homeostatic model assessment of insulin resistance; HOMA-IS: homeostasis model assessment of insulin secretion.
