Effects of 24 Weeks of Growth Hormone Treatment on Bone Microstructure and Volumetric Bone Density in Patients with Childhood-Onset Adult GH Deficiency
Table 4
Baseline and follow-up HR-pQCT parameters of the distal radius.
Baseline
24-week follow-up
Changes
value
Total vBMD (mg HA/cm3)
207.0 ± 68.0
208.1 ± 69.1
1.04 ± 12.08
0.802
Cortical area (mm2)
44.2 ± 8.4
46.5 ± 9.7
2.37 ± 4.85
0.181
Cortical vBMD (mg HA/cm3)
764.2 ± 79.3
751.5 ± 73.5
−12.66 ± 26.73
0.193
Cortical perimeter (mm)
74.1 ± 10.0
75.0 ± 10.9
0.50 (−0.30, 4.70)
0.034
Cortical thickness (mm)
0.602 (0.495, 1.187)
0.599 (0.500, 1.209)
0.034 ± 0.089
0.282
Intracortical porosity
0.004 ± 0.002
0.006 ± 0.004
0.002 ± 0.004
0.077
Trabecular area (mm2)
275.7 ± 75.5
273.5 ± 76.1
−2.13 ± 4.77
0.216
Trabecular vBMD (mg HA/cm3)
113.4 ± 36.4
110.2 ± 39.7
−3.20 ± 6.21
0.161
Trabecular thickness (mm)
0.208 ± 0.013
0.212 ± 0.013
0.004 ± 0.003
0.008
Trabecular number (1/mm)
1.363 ± 0.294
1.291 ± 0.325
−0.071 ± 0.078
0.025
Trabecular separation (mm)
0.743 ± 0.175
0.796 ± 0.199
0.053 ± 0.054
0.019
Tb.1/N.SD (mm)
0.292 ± 0.087
0.317 ± 0.096
0.024 ± 0.027
0.026
Trabecular bone volume fraction
0.168 ± 0.046
0.164 ± 0.050
−0.004 ± 0.007
0.134
Data are presented as mean ± SD or median and ranges. vBMD, volumetric bone mineral density; Tb.1/N.SD, Std. dev. of 1/Tb.N, inhomogeneity of network.
