Recurrent Germline Mutations of CHEK2 as a New Susceptibility Gene in Patients with Pheochromocytomas and Paragangliomas

Figure 3

Immunohistochemical staining of CHEK2 protein. (a) Staining for normal gland (positive control: the nucleus was positive for CHEK2). (b) Staining for PPGL tumor tissue with RET mutation (positive control: the nucleus was positive for CHEK2), (c) for Patient 1 (negative for CHEK2), (d) for Patient 2 (negative for CHEK2), (e) for Patient 3 (negative for CHEK2), and (f) for Patient 4 (the nucleus was negative but partial cytoplasm was weak positive for CHEK2).

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