International Journal of Endocrinology

Research Article

miR-141-3p is Poorly Expressed in Polycystic Ovary Syndrome and Correlates with Glucose and Lipid Metabolism

Table 2

Comparative analysis of the clinical data between PCOS patients and healthy controls.


Parameters	Control-nonobese (N = 70)	PCOS-nonobese	Control-obese	PCOS-obese
Parameters	Control-nonobese (N = 70)	(N = 57)	(N = 30)	(N = 43)

Age (years)	27.25 (25.07–30.38)	26.33 (24.31–30.19)	27.01 (24.22–30.14)	27.42 (24.53–30.60)	0.063	0.642	0.289
BMI (kg/m²)	21.00 (19.12–23.68)	20.75 (18.67–24.71)	27.76 (24.84–31.03)	28.55 (25.43–30.60)	0.693	0.253	<0.001
WHR	0.70 (0.62–0.81)	0.74 (0.65–0.82)	0.85 (0.71–1.00)	0.92 (0.82–1.02)	0.047	0.001	<0.001
TG (mmol/L)	1.18 (0.70–1.88)	1.33 (0.92–2.13)	1.36 (0.78–2.00)	1.51 (1.04–2.21)	0.001	0.003	0.014
TC (mmol/L)	1.10 (0.66–1.73)	1.13 (0.80–1.76)	1.19 (0.59–1.84)	1.30 (0.91–1.89)	0.232	0.319	0.334
LDL-C (mmol/L)	2.26 (1.85–2.85)	2.41 (1.89–2.85)	2.39 (1.82–3.01)	2.52 (1.99–2.91)	0.269	0.306	0.062
HDL-C (mmol/L)	1.09 (0.62–1.75)	0.75 (0.37–1.46)	1.24 (0.66–1.88)	0.64 (0.17–1.34)	<0.001	<0.001	0.031
FBG (mmol/L)	4.57 (3.89–5.55)	5.13 (3.57–6.47)	5.29 (4.26–6.44)	5.68 (4.73–6.61)	0.004	0.04	<0.001
FINS (mIU/L)	4.63 (3.76–5.88)	9.00 (7.33–10.43)	8.57 (7.72–9.53)	16.75 (15.31–18.17)	<0.001	<0.001	<0.001
HbAlc (%)	5.39 (4.89–6.11)	5.64 (4.85–6.32)	5.46 (4.67–6.35)	5.67 (5.06–6.26)	0.077	0.164	0.478
HOMA-β	81.50 (74.95–90.92)	118.26 (108.40–126.65)	94.28 (87.02–102.42)	156.6 (142.12–170.83)	<0.001	<0.001	<0.001
HOMA-IR	0.98 (0.92–1.05)	1.99 (1.83–2.13)	2.03 (1.90–2.17)	4.19 (3.95–4.43)	<0.001	<0.001	<0.001

Note. BMI, body mass index; WHR, waist-to-hip ratio; TG, triglyceride; TC, total cholesterol; LDL-C, low density lipoprotein cholesterin; HDL-C, high density lipoprotein cholesterin; FBG, fasting blood-glucose; FINS, fasting insulin; HbAlc, glycosylated hemoglobin; HOMA-β, homeostasis model assessment of beta cell function index; HOMA-IR, homeostasis model assessment of insulin resistance. P_a, PCOS-nonobese group vs control-obese group; P_b, PCOS-obese group vs control-obese group; P_c, PCOS-obese group vs PCOS-nonobese group.