Establishment and Validation of a Gene Signature-Based Prognostic Model to Improve Survival Prediction in Adrenocortical Carcinoma Patients

Figure 2

Gene signature-derived risk score serves as a risk factor and reliable predictor for overall survival in each cohort. (a–d) In the training cohort, the signature-based risk score was significantly elevated in patients who died during follow-up, especially in the short-term survival group. Kaplan–Meier survival analysis demonstrated a worse prognosis in patients with a high-risk score. Multivariate Cox regression analysis showed that risk score and TNM stage were independent risk factors for overall survival. At different time points, tROC analysis showed risk score was an accurate predictor for survival with even better performance than TNM stage. (e–h) Validation cohort I. (i–l) Validation cohort II.

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