The Beta-Cell Function and Glucose Profile of Newly Diagnosed Acromegalic Patients with Normal Glucose Tolerance
Table 1
General characteristics of the study participants.
Acromegaly
Control
P
n
8
8
Gender (male/female)
2/6
2/6
Age (years)
39.3 ± 9.6
38.0 ± 9.6
0.799
BMI (kg/m2)
24.69 ± 2.03
23.43 ± 2.73
0.311
HbA1c (%)
5.73 ± 0.30
5.35 ± 0.23
0.025
Nadir GH on OGTT (μg/L)
6.39 (2.73–12.12)
0.34 (0.12–0.48)
0.001
IGF-1 index
2.35 ± 0.42
0.62 ± 0.19
<0.001
BG0 (mmol/L)
5.14 ± 0.19
4.91 ± 0.38
0.156
BG120 (mmol/L)
6.63 ± 0.50
4.98 ± 1.43
0.014
INS0 (mU/L)
12.85 (12.33–23.43)
10.85 (6.28–13.00)
0.189
INS120 (mU/L)
112.85 (46.78–175.45)
34.05 (17.10–55.55)
0.009
Data are means ± SD or medians (25th–75th percentile). BMI: body mass index; BG0 and BG120: blood glucose levels in fasting and 120 min during OGTT. INS0 and INS120: insulin levels in fasting and 120 min during OGTT; IGF-1 index = IGF-1/age-appropriate upper limit of normal range (ULN).
