The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed Genes

Table 1

The detailed information of upregulated DEG enrichment in the functional enrichment analysis of APAs.

ID	Analysis type	Process	Count	value	Genes
hsa04020	KEGG pathway	Calcium signaling pathway	8	4.38X10^−6	CCKBR, PHKA1, HTR4, HTR2B, TACR1, ATP2A3, ATP2B2, ATP2B3
hsa04925	KEGG pathway	Aldosterone synthesis and secretion	6	8.73X10^−6	MC2R, CYP11B2, ATP2B3, PDE2A, ATP2B2, ATP1B1
hsa04024	KEGG pathway	cAMP signaling pathway	7	7.52X10^−5	CNGB3, MC2R, HTR4, ATP2B3, ATP2A3, ATP2B2, ATP1B1
GO: 1903779	Gene ontology	Regulation of cardiac conduction	4	1.37X10^−4	ATP1B1, ATP2A3, ATP2B3, ATP2B2
GO: 0030425	Gene ontology	Dendrite	9	1.71X10^−4	RELN, KCND3, HTR4, CYP46A1, SLC4A8, HTR2B, CTNND2
GO: 0045202	Gene ontology	Synapse	9	1.71X10^−4	GPC4, CHRNA5, CYFIP2, PMP22, HTR4, GJC1, HTR2B, CADM1, EEF1A2
GO: 0009311	Gene ontology	Oligosaccharide metabolic process	3	1.77X10^−4	ST3GAL6, NAGA, ST8SIA5
GO: 0055074	Gene ontology	Calcium ion homeostasis	3	2.00X10^−4	SGCD, WFS1, SNX10

DEG, differentially expressed gene; APA, aldosterone-producing adenoma.