Research Article
Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway
Figure 5
Effect of Sal in the expression of apoptotic and PERK/eIF2α signaling-related proteins. (a) Expression of Bcl-2 and the PERK/eIF2α signaling-related proteins PERK, p-PERK, eIF2α, p-eIF2α, ATF4 in SW-13 and NCI-H295 R cells, after treatment with 100 μm of Sal or not for 24 h. (b, c) Quantification of the expression levels of Bcl-2 and the PERK/eIF2α signaling-related proteins PERK, p-PERK, eIF2α, p-eIF2α, and ATF4 in A. The data are expressed as means ± SD (n = 3). , , and compared with control group.
(a) |
(b) |
(c) |