Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis

<div>PAX8-AS1 binds with miR-96-5p. <i>Note.</i> (a) ENCORI website showed two candidate miRNAs (miR-107 and miR-96-5p) holding binding sites with PAX8-AS1; (b) ENCORI website showed the expression of miR-96-5p and miR-107 in THCA tissues compared to normal tissues; (c) the expression of miR-96-5p in PTC cells compared to normal cells by qRT-PCR; (d) the transfection efficiency of miR-96-5p inhibitor in PTC cells was examined by qRT-PCR; (e) ENCORI website showed a binding region of miR-96-5p on PAX8-AS1; (f) the binding relationship of PAX8-AS1 and miR-96-5p was validated by luciferase reporter assay; <span class="nowrap"><svg height="11.6856pt" id="M4" style="vertical-align:-1.5831pt" version="1.1" viewbox="-0.0498162 -10.1025 209.803 11.6856" width="209.803pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 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International Journal of Endocrinology

fig3

Figure 3

Figure 3: Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis 