Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis

<div>miR-96-5p targets PKN2. <i>Note.</i> (a) ENCORI website showing six candidate target mRNAs of miR-96-5p; (b) the expression of six candidate mRNAs in PTC cells after downregulating miR-96-5p; (c) the protein level of PKN2 in PTC cells after miR-96-5p downregulation was detected by western blot; (d) TargetScan showed the binding region of miR-96-5p on PKN2; (e) the binding relationship between PKN2 and miR-96-5p was validated by luciferase reporter assay; (f) ENCORI website showed the expression of PKN2 in THCA tissues compared to normal tissues; (g) the expression of PKN2 in PTC cell lines compared to normal cells was assessed by qRT-PCR. <span class="nowrap"><svg height="11.6856pt" id="M6" style="vertical-align:-1.5831pt" version="1.1" viewbox="-0.0498162 -10.1025 209.803 11.6856" width="209.803pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 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International Journal of Endocrinology

fig5

Figure 5

Figure 5: Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis 