FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis

<div>Expression of <i>Foxa3</i> mRNA decreases during cAMP induction in MA-10 Leydig cells. Time-dependent expression of <i>Foxa3</i> decreases up to 4 hours and is restored at 6 h (A), whereas the expression of Nur77 is strongly induced at 2 h and then decreases (B) in cAMP-induced MA-10 cells. <i>Nur77</i> expression at 2 h and <i>Foxa3</i> expression at 0 h were considered 100% for relative comparison. The gene expression level was normalized to that of <i>β</i>-actin. 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International Journal of Endocrinology

fig1

Figure 1

Figure 1: FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis 