Long-Term Oncological Outcome Comparison between Intermediate- and High-Dose Radioactive Iodine Ablation in Patients with Differentiated Thyroid Carcinoma: A Propensity Score Matching Study
Table 3
Univariate and multivariate analyses of recurrence risk factors before propensity score matching.
Univariate
Multivariate
HR (95% CI)
value
HR (95% CI)
value
Age
0.962 (0.940–0.984)
0.001
Extent of operation
TT
Ref.
TT and mRND
2.009 (1.114–3.621)
0.020
Tumor size
1.382 (1.119–1.707)
0.003
ETE
2.629 (1.379–5.013)
0.003
Lymphatic invasion
2.734 (1.531–4.884)
0.001
Vascular invasion
4.114 (1.855–9.123)
0.001
Perineural invasion
3.185 (1.267–8.010)
0.014
2.918 (1.147–5.217)
0.025
Harvested LNs
1.017 (1.008–1.025)
<0.001
Positive LNs
1.062 (1.045–1.080)
<0.001
1.039 (1.019–1.059)
<0.001
LN ratio
≤0.22
Ref.
Ref.
>0.22
3.513 (1.928–6.401)
<0.001
2.373 (1.260–4.469)
0.007
ATA risk stratification
Low
Ref.
Intermediate
4.348 (1.344–14.069)
0.014
High
7.734 (2.128–28.104)
0.002
T stage
T3b
2.919 (1.511–5.637)
0.001
N stage
N0
Ref.
N1a
2.589 (1.006–6.662)
0.048
N1b
4.264 (1.561–11.650)
0.005
Pre-op. serum Tg
1.003 (1.002–1.005)
<0.001
≤10 ng/mL
Ref.
>10 ng/mL
2.242 (1.197–4.201)
0.012
Post-RAI serum Tg
1.005 (1.002–1.008)
0.001
≤1 ng/mL
Ref.
>1 ng/mL
3.257 (1.788–5.934)
<0.001
≤10 ng/mL
Ref.
Ref.
>10 ng/mL
5.976 (3.434–10.401)
<0.001
4.504 (2.521–8.045)
<0.001
Post-RAI serum TgAb
Negative
Ref.
Ref.
Positive
2.271 (1.069–4.825)
0.033
2.567 (1.197–5.508)
0.015
Tg. ratio
≤0.077
Ref.
>0.077
2.264 (1.256–4.079)
0.007
Data are expressed as hazard ratio (HR) and 95% confidence interval (CI). A value <0.05 was considered statistically significant. LN ratio is defined as the number of positive LNs divided by the number of harvested LNs. Tg ratio is defined as post-RAI Tg/preop Tg. Abbreviation: TT, total thyroidectomy; mRND, modified radical neck dissection; ETE, extrathyroidal extension; LN, lymph node; T, tumor; N, node; ATA, American thyroid association; pre-op, preoperative; post-RAI, after radioactive iodine therapy; Tg, thyroglobulin; TgAb, thyroglobulin antibody.
