Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS

Table 1

Comparison of allele frequency, genotype distribution, and genotype association models of INSR exon 17 C/T SNP in PCOS and control women.

	Allele/genotype	Cases (n = 249)	Controls (n = 100)	Total (n = 349)	OR (95% CI)	χ^2 ()
Allele frequency	C	386 (77.5%)	155 (77.5%)	541	1.00 (0.67–1.48)	0.01 (0.99)
	T	112 (22.5%)	45 (22.5%)	157
Genotype distribution	CC	156 (62.65%)	67 (67.00%)	223 (63.90%)	—	3.73 (0.15)
	CT	74 (29.72%)	21 (21.00%)	95 (27.22%)
	TT	19 (7.63%)	12 (12.00%)	31 (8.88%)
Association models	CC + CT vs. TT	230 (92.4%) vs. 19 (7.6%)	88 (88%) vs. 12 (12%)	—	0.605 (0.28–1.29)	1.68 (0.19)
	CC vs. CT + TT	156 (62.7%) vs. 93 (37.3)	67 (67%) vs. 33 (33%)	—	1.21 (0.74–1.97)	0.58 (0.44)
	CT vs. CC + TT	33 (13.2%) vs. 216 (87.9%)	16 (16%) vs. 84 (84%)	—	1.25 (0.65–2.38)	0.45 (0.5)

PCOS: polycystic ovary syndrome, C T: alleles for INSR C/T polymorphism, CI: confidence interval, and Χ²: chi-square test with yates correction. Data of alleles are presented as number (%) of PCOS cases and controls. GG GA and AA are genotypes of IRS 1 (G/A) polymorphism in PCOS and controls, and Χ²: Pearson’s chi-square test, () value data of alleles is presented as number (%) of PCOS cases and controls.