Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS

Table 2

Comparison of anthropometric, clinical, hormonal, metabolic, and biochemical parameters in dominant genotype model for INSR rs1799817 SNP in PCOS women.

Parameter	PCOS		value	Controls		value
	CC + CT (n = 230)	TT (n = 19)		CC + CT (n = 88)	TT (n = 12)
Age (years)	22.48 ± 4.19	21.88 ± 3.64	0.54	22.03 ± 3.15	21.83 ± 3.46	0.83
Weight (kg)	59.86 ± 11.71	61.53 ± 11.18	0.54	51.64 ± 6.61	54.17 ± 7.37	0.22
Height (m)	1.57 ± 0.05	1.55 ± 0.04	0.09	1.56 ± 0.05	1.58 ± 0.07	0.21
BMI (kg/m^2)	24.23 ± 4.74	25.55 ± 4.37	0.24	21.08 ± 2.42	21.75 ± 2.89	0.38
Waist (cm)	83.17 ± 11.25	82.76 ± 10.74	0.87	76.59 ± 6.68	80.08 ± 9.47	0.11
Hip (cm)	93.39 ± 8.37	95.00 ± 7.57	0.48	90.82 ± 5.88	94.83 ± 8.46	0.03
WHR	0.89 ± 0.08	0.88 ± 0.07	0.59	0.84 ± 0.05	0.84 ± 0.06	1.00
WHtR	0.53 ± 0.07	0.53 ± 0.07	1.00	0.49 ± 0.04	0.51 ± 0.06	0.13
BAI	29.44 ± 4.78	31.18 ± 3.68	0.12	28.46 ± 3.01	29.80 ± 3.13	0.15
SBP (mmHg)	120.88 ± 7.45	118.41 ± 8.12	0.16	118.59 ± 5.49	121.67 ± 3.89	0.06
DBP (mmHg)	80.86 ± 5.87	80.65 ± 6.38	0.88	79.01 ± 5.34	81.58 ± 3.70	0.11
Menarche (yr)	13.14 ± 1.14	12.88 ± 1.17	0.34	13.30 ± 1.11	13.17 ± 0.83	0.69
FG score	13.99 ± 6.60	15.71 ± 6.59	0.27	4.59 ± 1.79	4.08 ± 2.23	0.37
LH (IU/L)	11.36 ± 9.82	10.15 ± 5.15	0.59	6.74 ± 2.37	6.00 ± 2.19	0.30
FSH (IU/L)	6.15 ± 1.85	5.77 ± 2.08	0.39	6.91 ± 1.99	6.83 ± 1.94	0.89
TT (ng/dL)	60.62 ± 21.28	72.31 ± 38.94	0.03	33.85 ± 15.06	36.32 ± 19.75	0.60
SHBG (nmol/L)	50.20 ± 21.75	49.31 ± 21.69	0.86	66.13 ± 25.51	55.97 ± 23.89	0.19
Andro (ng/mL)	3.26 ± 0.87	3.16 ± 0.79	0.62	2.22 ± 0.69	2.52 ± 0.62	0.15
DHEAS (ng/mL)	3.79 ± 1.16	3.74 ± 1.08	0.85	2.78 ± 1.29	3.83 ± 1.02	0.00
Insulin (μIU/ml)	13.29 ± 6.88	15.29 ± 7.94	0.23	7.52 ± 4.78	9.17 ± 8.88	0.32
Glu F (mg/dL)	85.60 ± 8.51	88.35 ± 10.01	0.18	84.17 ± 8.97	87.25 ± 7.88	0.26
Glu 2 h (mg/dL)	114.72 ± 18.08	122.18 ± 18.89	0.08	108.23 ± 12.83	110.92 ± 23.00	0.54
Chol (mg/dL)	154.80 ± 35.04	156.00 ± 31.43	0.88	133.58 ± 19.14	146.33 ± 17.29	0.03
TG (mg/dL)	120.78 ± 35.62	119.88 ± 38.82	0.91	102.76 ± 14.54	102.50 ± 17.13	0.95
HOMA-IR	2.85 ± 1.62	3.71 ± 1.92	0.02	1.56 ± 1.01	2.04 ± 2.03	0.18
QUICKI	0.33 ± 0.02	0.32 ± 0.02	0.03	0.37 ± 0.04	0.39 ± 0.08	0.16
FAI	5.76 ± 5.72	6.33 ± 4.30	0.67	2.17 ± 1.70	2.53 ± 1.33	0.48
LH:FSH	1.88 ± 1.22	1.84 ± 1.09	0.89	1.05 ± 0.57	0.91 ± 0.29	0.40
LAP	35.51 ± 21.74	35.43 ± 22.71	0.98	21.69 ± 8.52	25.94 ± 12.29	0.12
Urea	22.63 ± 6.09	23.88 ± 5.19	0.38	21.34 ± 3.58	21.12 ± 2.62	0.83
Cre (mg/dL)	1.04 ± 0.43	0.85 ± 0.20	0.05	0.81 ± 0.14	0.78 ± 0.12	0.48
AST (U/L)	31.24 ± 12.40	36.12 ± 13.12	0.10	18.36 ± 8.20	17.85 ± 4.67	0.83
ALT (U/L)	28.23 ± 14.18	23.18 ± 7.11	0.12	23.22 ± 6.85	25.21 ± 6.29	0.34

Data presented as mean ± SD. value <0.05 significant. values calculated by independent Student’s t test. PCOS: polycystic ovary syndrome, BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, men: menarche, FG score: Ferriman–Gallwey score, LH: luteinizing hormone, FSH: follicle-stimulating hormone, TT: total testosterone, PRL: prolactin, TSH: thyroid-stimulating hormone, SHBG: sex hormone-binding globin, andro: androstenedione, DHEAS: dehydroepiandrosterone sulfate, Glu F: glucose fasting, CHOL: cholesterol, TG: triglycerides, HOMA: IR homeostasis model assessment-estimated insulin resistance, QUICKI: quantitative insulin sensitivity check index, FAI: free androgen index, UA: uric acid, Cre: creatinine, AST: aspartate aminotransferase, and ALT: alanine aminotransferase.